Implant vs. gel: which hormone delivery wins for menopause?

NCT ID NCT07754630

Ongoing Disease control Sponsor: Nutrindo Ideais Research Center Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests two ways of delivering the hormone estradiol to women going through menopause: a small implant placed under the skin versus a daily gel applied to the skin. The study will measure hormone levels in the blood and track how well each method eases menopause symptoms like hot flashes. Fifty women aged 41 to 59 with low estrogen will be randomly assigned to one of the two treatments and followed for six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: estradiol (as a subcutaneous implant or transdermal gel)
What this could lead to: If successful, this could help doctors choose the best way to deliver hormone therapy for menopause, potentially improving symptom relief and quality of life.
What could go wrong: This is a small, early-stage trial, so results may not apply to all women. Hormone therapy carries risks, including blood clots and breast cancer, which the study will monitor.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HORMONAL THERAPY HYPOESTROGENISM MENOPAUSE

Contacts and locations

Locations

Nutrindo Ideais Research Center

Rio de Janeiro, Rio de Janeiro, 22421000, Brazil

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