MENOPAUSE

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This study tests whether a set of lifestyle interventions can help women going through menopause reduce inflammation, improve heart health, slow biological aging, and ease symptoms like hot flashes. Researchers will enroll 200 women aged 45-55 who are in late menopause transition…

This study looks at whether combining time-restricted eating (eating only during an 8-hour window) with a low-glycemic Mediterranean diet can improve memory, thinking, and overall health in women going through menopause. About 72 women aged 45-75 with a BMI of 23 or higher will b…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study looks at whether drinking beetroot juice every day for 12 weeks can help postmenopausal women get more heart and blood vessel benefits from exercise. The researchers will compare two groups of women doing the same exercise program—one group gets real beetroot juice, th…

This study looks at whether hormone therapy (estrogen with or without progesterone) can safely reduce hot flashes and night sweats in women living with HIV. Researchers will also check if it improves sleep, mood, thinking, bone health, and quality of life. About 105 women aged 40…

This study tests whether a combined program of education and exercise (including strength and pelvic floor training) can improve physical, functional, and psychological well-being in women aged 45 and older who are going through menopause. Over 8 weeks, participants attend two su…

This study tests if an online avatar-based education and counseling program can increase support from spouses during menopause. About 280 menopausal women and their partners will take part, with some receiving the avatar program and others getting usual care. The goal is to see i…

This study tracks 100 women aged 40 and older with low estrogen (due to menopause or surgery) to see how well they follow a 12-week creatine supplement routine. Researchers will measure adherence, satisfaction, and any changes in muscle strength, body composition, quality of life…

This study tests whether a daily probiotic drink can improve immune function and reduce skin inflammation in women aged 40-60 going through menopause. Participants will drink either a probiotic or a plain milk drink for 8 weeks. Researchers will measure immune aging, inflammation…

This study tests an 8-week home exercise program delivered through a smartphone app for women aged 45-65 who are in early menopause (within 6 years of their last period). The goal is to see if the program improves quality of life, muscle strength, balance, and physical performanc…

This study tests whether training the muscles you use to breathe in can help midlife women with hot flashes, sleep problems, and blood pressure. Thirty women aged 45-60 will use a breathing device daily for 6 weeks. Researchers will measure changes in hot flash frequency, sleep q…

This study looks at whether a plant-based supplement (sarmentosin and L-theanine) combined with home strength training can improve mood, sleep, and muscle health in women going through perimenopause. 72 women aged 40-55 will be split into four groups: supplement plus exercise, su…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study tests whether hemp-derived cannabinoids can help with menopause symptoms like depression, anxiety, and hot flashes. Researchers will give 104 women either a hemp product or a placebo for several weeks. Participants track their symptoms daily and monthly through surveys…

This study tests if eating only during an 8-hour window each day (16-hour fast) helps menopausal women lose weight and reduce menopause symptoms. It includes women going through natural menopause or those with hormone-sensitive breast cancer. 84 participants will be randomly assi…

This study tests whether a daily probiotic supplement can help reduce menopause symptoms like hot flashes and night sweats, and improve quality of life. The trial will include 140 peri- or post-menopausal women who have frequent symptoms. Participants will take either the probiot…

This study tests whether hormone replacement therapy (HRT) or cognitive behavioral therapy (CBT-I) can help perimenopausal women sleep better. Fifty-four women with insomnia and hot flashes will receive either HRT, weekly CBT-I sessions, or sleep hygiene tips for 8 weeks. Researc…

This study tests small hormone implants placed under the skin to relieve menopause symptoms like hot flashes, low mood, and sexual problems. It includes 140 women with natural menopause, early ovarian failure, or menopause from cervical cancer treatment. Researchers will check ho…

This study looks at how estrogen levels affect the way women's bodies handle heat stress. Researchers will compare premenopausal and postmenopausal women aged 42-64, using drugs to temporarily adjust estrogen levels. The goal is to understand why older women are at higher risk du…

This study investigates how estrogen influences muscle growth and function in post-menopausal women during a 12-week exercise program. Researchers will measure changes in muscle mass, strength, and cellular health, focusing on muscle stem cells and mitochondria. The goal is to un…

This study at Mayo Clinic looks at how hot flashes in women may be connected to problems with blood vessels and nerves that control blood pressure. Researchers will measure nerve activity and blood vessel function in 120 women with different levels of hot flashes. The goal is to …

This study aims to find small molecules called microRNAs in the blood that can predict how well two osteoporosis drugs (romosozumab and abaloparatide) work in postmenopausal women. Researchers will measure bone density and blood markers over 12 months in 42 women. The goal is to …

The AGEWISE study is observing 300 healthy women aged 40 to 64 in Portugal to understand how gut bacteria change with hormones during menopause. Participants provide stool and blood samples and answer health and diet questionnaires. Researchers hope to uncover connections between…

This national study in Brazil will survey about 1,600 women aged 35 to 65 who are going through or have completed menopause. Researchers want to learn how factors like income, region, and access to healthcare affect women's health, quality of life, and knowledge about menopause. …

This study follows 80 women aged 45-55 as they go through menopause to see how their nerves and blood vessels change. Researchers will measure nerve activity and blood vessel function each year, or every six months once perimenopause starts. The goal is to understand why menopaus…

This study looks at what happens to the heart and breathing during a hot flush in postmenopausal women. Researchers will use heating pads and warm items to trigger hot flushes in a controlled setting. They want to see if these induced flushes cause similar changes in blood pressu…

This study looks at how menopause and hormone replacement therapy (HRT) change the way the brain talks to muscles. Twenty women who are about to start HRT will be tested before starting, after two months, and after five months of treatment. They also get a voluntary 12-week exerc…

This study looks at whether menopause and HIV together increase heart disease risk in women. Researchers will examine inflammation and body fat using MRI scans and blood tests in 90 women with HIV. The goal is to understand why heart risks may worsen after menopause in this group…

This study looks at how early menopause (before age 45) affects the nerves that control blood pressure. Researchers will measure nerve activity and blood pressure in 160 women aged 35-70. The goal is to understand why these women may have higher blood pressure and find ways to he…

This study looks at why depression and heart disease often occur together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55. The goal is to find clues that could lead to better ways to reduce heart disease ri…

This study looks at how the nervous system controls blood flow in women going through menopause. Researchers will measure nerve activity and blood vessel responses in 75 women aged 18-70. They will also test how two drugs (propranolol and phentolamine) affect these responses. The…

This study examines how aging and menopause change the way blood vessels widen in response to low oxygen. Researchers will give healthy women either a placebo, a beta-blocker (propranolol), or a bladder medication (gemtesa) to see how these drugs affect blood flow in the forearm.…