Could estrogen explain why older women suffer more in heat waves?

NCT ID NCT06798571

Recruiting now Knowledge-focused Sponsor: Penn State University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how estrogen levels affect the way women's bodies handle heat stress. Researchers will compare premenopausal and postmenopausal women aged 42-64, using drugs to temporarily adjust estrogen levels. The goal is to understand why older women are at higher risk during heat waves, which could lead to better protection strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elagolix (Orilissa) and estradiol patch
What this could lead to: If successful, this could help explain why older women are more vulnerable to heat waves and point toward ways to protect them.
What could go wrong: This is a small, early-phase study (24 participants) focused on basic body responses, not a treatment. Results may not apply to all women or lead to direct health advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Heat Stress Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING MENOPAUSE

Contacts and locations

Locations

Noll Laboratory
RECRUITING

University Park, Pennsylvania, 16802, United States

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