Hormone implants could ease menopause symptoms for years

NCT ID NCT06343870

Recruiting now Symptom relief Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests small hormone implants placed under the skin to relieve menopause symptoms like hot flashes, low mood, and sexual problems. It includes 140 women with natural menopause, early ovarian failure, or menopause from cervical cancer treatment. Researchers will check hormone levels, quality of life, and safety over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: estradiol and testosterone subdermal implants
What this could lead to: If successful, this could offer a convenient, long-lasting treatment option for menopause symptoms like hot flashes and low sexual desire.
What could go wrong: This is a phase 3 trial, but it is still relatively small (140 participants) and results may not apply to all women. Hormone therapy carries risks like blood clots, which the study will monitor.

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Conditions

The condition(s) this trial relates to.

cervical cancer hypogonadism hypogonadism, male premature menopause

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESTROGEN DEFICIENCY MENOPAUSE TESTOSTERONE DEFICIENCY

Contacts and locations

Locations

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
RECRUITING

São Paulo, São Paulo, 05401-000, Brazil

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