University Of Sao Paulo General Hospital

This study tests whether a high dose of the drug cabergoline given for about 6 months can cure small pituitary tumors (microprolactinomas) in women. Currently, standard treatment uses the lowest effective dose for 2 years. The goal is to see if the short high-dose approach leads …

This study is testing a live attenuated dengue vaccine (Butantan-DV) in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable and on low or no immune-suppressing drugs. Researchers want to see if the vaccine triggers a good immun…

This study compares two types of mesh surgery for women with pelvic organ prolapse (when organs slip out of place). One approach uses vaginal mesh, the other uses robotic-assisted abdominal mesh. Researchers want to see if vaginal mesh works just as well and is as safe as the rob…

This study looks at 150 women having heart bypass surgery to see which type of graft—a vein from the leg or an artery from the arm—works better for the second most important heart artery. The goal is to find out which graft stays open longer and causes fewer problems. Participant…

This study tests a 12-week group exercise program for the feet and ankles of people with diabetes who have nerve damage. The goal is to see if these exercises can reduce symptoms, improve movement, and boost quality of life. About 356 adults will take part through their local hea…

This study is testing whether the shingles vaccine works and is safe for adults with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are taking immune-suppressing drugs. About 200 participants will receive two doses of the vaccine. Researchers will measure …

This study tests whether small hormone implants placed under the skin can help women with menopause symptoms like hot flashes, low sex drive, and vaginal dryness. It includes women who went through natural menopause, early menopause, or menopause after cervical cancer treatment. …

This study tests whether watching weekly video lessons instead of reading text can help adults with binge eating disorder stop binge eating. Eighty participants will receive either video or text-based therapy plus brief online guidance sessions. The goal is to see if video lesson…

This study tests whether a treatment called extracorporeal shock wave therapy (ESWT) can reduce pain and improve jaw movement in people with painful jaw muscle disorders (TMD). About 100 adults with moderate to severe jaw pain for at least 3 months will receive either real or fak…

This study tests whether a stabilizing mouth splint can reduce tinnitus (ringing in the ears) in people who also have temporomandibular joint (TMJ) disorders. Researchers will compare the splint to a placebo in 63 adults over 4 months. The goal is to see if treating the jaw probl…

This study looks at two ways to improve screening for diabetes after pregnancy in women who had gestational diabetes. First, it tests whether sending reminders through WhatsApp helps more women come in for a glucose test. Second, it compares a newer way of reading the test result…

This study looks at whether a non-invasive, radiation-free bedside tool called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of people undergoing surgery to remove old blood clots. About 36 adults with chronic thromboembolic pulmonary hyperten…

This study looks at whether tiny particles released by cells into the blood, called extracellular vesicles, can help detect heart damage from ATTR amyloidosis earlier and less invasively. Researchers will compare these particles in 70 people with different stages of the disease a…