University Of Sao Paulo General Hospital

This study tests if the inhaled drug iloprost can safely lower high blood pressure in the lungs (pulmonary hypertension) of people with severe COPD. Fifteen adults will take iloprost 6-9 times daily for 12 weeks. Researchers will measure changes in lung blood pressure and walking…

This study looks at whether giving a single dose of amoxicillin before a simple tooth extraction can lower the chance of infection in people with autoimmune rheumatic diseases who take immune-suppressing drugs. About 352 adults will take part, and half will get the antibiotic whi…

This study looks at whether changing from an inhaled medication (iloprost) to a pill (selexipag) can improve quality of life and treatment satisfaction for people with pulmonary arterial hypertension (PAH). About 32 adults whose doctor has already decided to switch treatments wil…

This study will test a smartphone app called CONEMO to help adults with depression, anxiety, and insomnia. About 12,400 people from primary care clinics in Brazil will use the app to track and improve their symptoms. The goal is to see if the app helps people feel better and redu…

This study tests whether low-intensity focused ultrasound (LIFU) can safely reduce tremors and improve quality of life in people with essential tremor whose medications aren't working well. Twenty adults will receive both real LIFU and a sham (fake) treatment in separate sessions…

This study uses a short questionnaire to learn where patients with pulmonary hypertension and their caregivers search for health information, what topics they look for, and how satisfied they are with what they find. About 100 adults with a confirmed diagnosis or their informal c…

This study will collect information from 1,000 newborns with esophageal atresia (a birth defect where the esophagus doesn't form correctly) across 72 hospitals in Brazil. Researchers aim to identify factors that lead to complications or death, and use this knowledge to improve tr…

This study follows 400 people who come to the emergency room with sudden vertigo or dizziness that might be caused by a mini-stroke in the back of the brain. Doctors will track their symptoms, treatments, and outcomes over a year to learn how to better tell these dangerous episod…