University Of Sao Paulo General Hospital

This study is testing whether a single-dose dengue vaccine is safe and works well for people with autoimmune diseases like rheumatoid arthritis or lupus. Researchers will compare about 320 patients with these conditions to 160 healthy volunteers, all living in areas where dengue …

This study aims to see if a meningitis B vaccine is safe and effective for children and teenagers who have autoimmune diseases like lupus or juvenile arthritis. Researchers will give the vaccine to about 260 participants, including both patients and healthy children for compariso…

This study aims to see how well patients with a serious type of high blood pressure in the lungs, caused by chronic lung diseases, fare over time when treated with an inhaled medication called iloprost. It will look back at the medical records of about 50 adults who have already …

This study aims to understand if switching adults with pulmonary arterial hypertension (PAH) from a medication they inhale several times a day to a pill taken twice daily improves their quality of life and makes it easier to stick with treatment. Researchers will follow 32 patien…

This study aims to roll out and test a smartphone app called CONEMO to help adults manage symptoms of depression, anxiety, and insomnia. It will involve over 12,000 people who use primary healthcare services in two Brazilian cities. The goal is to see how well this proven digital…

This study is testing whether an inhaled medication called iloprost is safe and effective for treating high blood pressure in the lungs of adults with severe COPD. Researchers want to see if the drug lowers pressure in the lung's blood vessels and helps people walk farther. Fifte…

This study aims to see if a newer, less-studied video scope (BESDATA BD-DF) works as well as a more common one (McGRATH MAC) for safely placing a breathing tube in infants and young children during surgery. Researchers will compare how often each device succeeds on the first try,…

This study aims to help women who had diabetes during pregnancy (gestational diabetes) get an important follow-up blood sugar test after giving birth. Researchers will test if sending reminder messages via WhatsApp increases the number of women who attend their scheduled test. Th…

This study aims to find the best way to teach young people how to prevent burns and give proper first aid. Researchers will compare a new educational video game against a traditional classroom lecture. They will measure which method helps 44 student participants learn and remembe…

This study tests if taking a daily antiviral pill (acyclovir) can prevent painful and frequent herpes outbreaks in people with autoimmune diseases like lupus or arthritis. These patients often take medications that weaken their immune system, making them more prone to infections.…

This study aims to find out if a single dose of an antibiotic is needed to prevent infection after a simple tooth extraction in people with autoimmune diseases who are on medications that weaken their immune system. It will compare the antibiotic amoxicillin to a placebo (a dummy…

This study aims to see if temporarily stopping a common arthritis drug (methotrexate) for two weeks after getting a pneumonia vaccine helps the body build stronger protection. It will involve 192 adults with stable autoimmune diseases like rheumatoid arthritis. Researchers will c…

This study is testing a gentle, non-invasive form of ultrasound aimed at a specific part of the brain to see if it can reduce shaking (tremor) in people with essential tremor. Twenty adults whose tremor isn't well-controlled by medication will receive both a real and a fake (sham…

This study aims to learn where patients with pulmonary hypertension and their caregivers look for health information and what topics they search for most. Researchers will survey 100 patients and 100 caregivers using a short questionnaire about their information sources, satisfac…

This study aims to better understand and diagnose people who experience brief episodes of vertigo or dizziness that last less than a day. Researchers will observe 400 patients over time to see how their diagnosis might change, what treatments they receive, and what their health o…

This study aims to understand how newborns in Brazil with esophageal atresia—a rare birth defect where the food pipe doesn't form properly—are treated and what their outcomes are. It will collect data from 72 hospitals across the country on 1000 babies to identify what factors le…