University Of Sao Paulo General Hospital

This study tests whether the drug liraglutide, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight and improve heart function. Thirty children will receive either liraglutide injections plus lifestyle advice or lifestyle advice …

This study tests a minimally invasive heart bypass surgery for people with blockages in multiple coronary arteries. Instead of opening the chest fully, surgeons work through a small incision on the left side. The goal is to see if this approach is safe and effective, with fewer c…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This study tests whether watching short video lessons instead of reading chapters can help adults with binge eating disorder stop binge eating. Eighty adults will either watch weekly videos or read text-based materials for 13 weeks, with brief online coaching sessions. The goal i…

This study looks at immune system markers in the saliva and blood of 80 people with primary Sjögren's syndrome, a chronic disease causing dry eyes and mouth. Researchers will check for antibodies that may block a key enzyme and see how gum disease affects symptoms. The goal is to…

This small, early study is testing whether spironolactone, a drug already approved for high blood pressure, can reduce the hidden HIV reservoir in people on effective HIV treatment. Researchers will give the drug to 12 adults (both with and without HIV) to see how it affects a ke…

This study is creating a risk score called CABG-BraSCORE to better predict outcomes for people having coronary artery bypass surgery in Brazil. Researchers will collect data from 2,400 patients across multiple hospitals to see how factors like age and health affect risks like dea…