Old drug, new trick: can spironolactone silence HIV?

This small, early study is testing whether spironolactone, a drug already approved for high blood pressure, can reduce the hidden HIV reservoir in people on effective HIV treatment. Researchers will give the drug to 12 adults (both with and without HIV) to see how it affects a key protein and how the body processes it. The goal is to gather initial safety and biological data to see if spironolactone could one day be part of an HIV cure strategy.