University Of Sao Paulo General Hospital

This study is observing what happens when adults with pulmonary arterial hypertension (PAH) switch from one standard medication (ambrisentan) to another (bosentan). Researchers will track 121 patients for 3-6 months to see if this change affects their overall risk score, which pr…

This study is testing whether a digital platform based on Enhanced Recovery After Surgery (ERAS) principles can help patients recover more quickly after heart bypass surgery. It will involve 480 adults in Brazil who are scheduled for this surgery and have a smartphone. The main g…

This study is testing a new treatment strategy for small, benign pituitary tumors that cause excess prolactin hormone. It compares a short, high-dose course of the standard drug cabergoline (about 6 months) against the usual long-term, low-dose treatment (2 years). The goal is to…

This study is testing whether a 12-week supervised foot and ankle exercise program can help people with diabetes manage foot problems and improve their quality of life. Researchers will train healthcare workers to deliver the program in local clinics and monitor 356 participants …

This study aims to find out if a vaginal mesh surgery is as good as a robotic abdominal mesh surgery for treating pelvic organ prolapse in women. Researchers will compare how well each procedure fixes the prolapse and how safe they are. The study will involve 86 women with modera…

This study is testing if a temporary nerve block in the neck can help control dangerous, repeated episodes of fast heart rhythms (called an electrical storm) in patients who don't respond to initial medications. Patients will be randomly assigned to receive either the nerve block…

This study is testing whether having a pharmacist provide support and education can help people with pulmonary arterial hypertension (PAH) stick to their prescribed inhaled medication. PAH is a serious lung condition where survival is often limited. The research will see if this …

This study compares two different blood vessel grafts used during heart bypass surgery in women. Researchers want to see whether using a vein from the leg (with a special 'no-touch' technique) or an artery from the arm works better for keeping blood flowing to the heart long-term…

This study is testing if a therapy program for binge eating disorder works better when delivered through weekly video lessons instead of traditional book readings. 80 adults with binge eating disorder will be randomly assigned to either watch videos or read text, while both group…

This study is testing a new, non-invasive scanning method to diagnose high blood pressure in the lungs (pulmonary hypertension). Researchers will compare a safe, bedside scan using an electrode belt against the current invasive standard test in 120 patients. The goal is to see if…

This study is testing how well a newer pneumonia vaccine works and how safe it is for children and young adults (ages 2-25) who have autoimmune rheumatic diseases like juvenile arthritis or lupus. These patients are at higher risk for infections, and the research will measure the…

This study is testing how well the newer shingles vaccine works for adults who have autoimmune diseases like rheumatoid arthritis or lupus and are taking certain medications. Researchers will give 200 participants two doses of the vaccine and then check their immune response and …

This study is testing whether a non-invasive treatment called focal shock wave therapy can help reduce pain and improve jaw movement for people with chronic jaw muscle disorders. One hundred participants will receive either the real shock wave treatment or a placebo version over …

This study is testing if a custom-made dental mouthguard can help reduce tinnitus (ringing in the ears) that is linked to jaw joint problems. Researchers will compare the real mouthguard to a placebo version in 63 adults who have had both conditions for over six months. The main …

This study aims to find the best way to relieve vaginal dryness in women with Sjögren's disease, a condition that causes severe dryness throughout the body. Researchers will compare a vaginal CO2 laser treatment with a topical hormone cream (promestriene) over six months. The goa…

This study is testing a small, dissolvable hormone implant placed under the skin to relieve common symptoms of menopause, such as hot flashes and sexual discomfort. It will involve 140 women who are experiencing menopause naturally, prematurely, or due to surgery for cervical can…

This study is testing if a medication called clonidine can help reduce cravings in people hospitalized for cocaine or crack addiction. It will compare clonidine to another medication, clonazepam, over two weeks. The main goal is to see which drug better lowers the patients' self-…

This study aims to understand why it takes so long for patients in Brazil to get diagnosed with pulmonary arterial hypertension (PAH) and other rare diseases. Researchers will review medical records of 139 adults diagnosed within the last five years to track their journey from fi…

This study aims to find better ways to detect heart damage from ATTR amyloidosis, a condition where abnormal proteins build up in the heart. Researchers will analyze tiny particles in the blood of 70 people, including those with the disease, those at risk, and healthy individuals…

This study is creating and testing a questionnaire to find out what patients with pulmonary arterial hypertension (PAH) know about their condition. Researchers will work with about 200 patients to make sure the questions are clear and measure knowledge accurately. The goal is to …