University Of Sao Paulo General Hospital

This study is testing the meningococcal B vaccine (Bexsero) in children and young adults aged 2 to 25 who have autoimmune rheumatic diseases like juvenile arthritis or lupus. Researchers want to see if the vaccine triggers a strong immune response and if it is safe, especially fo…

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This study tests the safety and immune response of the 20-valent pneumococcal vaccine (PCV20) in children, adolescents, and young adults aged 2-25 with autoimmune rheumatic diseases like juvenile arthritis. All 114 participants will receive one dose of PCV20, and researchers will…

This study compares a standard leg exercise program alone versus the same program combined with neuromuscular electrical stimulation (NMES) in heart failure patients who have a temporary heart pump (intra-aortic balloon pump) in their leg. The goal is to see if adding NMES helps …

This phase 2 trial tests a new radiation technique called SBRT-LATTICE-PATHY for people with large tumors (at least 7 cm or 340 cm³) that cannot be treated with standard methods. The approach delivers a high dose of radiation only to low-oxygen areas inside the tumor, aiming to i…

This study tests whether a higher dose of the drug cabergoline, taken for about 6 months, can achieve lasting remission in women with small prolactinomas (non-cancerous pituitary tumors that cause excess prolactin). 70 premenopausal women will be randomly assigned to either the h…

This study tests whether extra guidance from a pharmacist can help people with pulmonary arterial hypertension (PAH) use their inhaled iloprost correctly and consistently. PAH is a rare, serious lung condition that makes it hard to breathe. The trial will enroll 72 adults who alr…

This study tests whether a 12-week program of supervised foot and ankle exercises can help people with diabetes who have nerve damage in their feet. The exercises are done in groups at primary care clinics. Researchers will measure changes in symptoms, foot movement, and quality …

This study compares two surgical methods using mesh to treat pelvic organ prolapse in women. One approach uses vaginal mesh, the other uses robotic-assisted abdominal mesh. The goal is to see if vaginal mesh works as well as the robotic method and is just as safe. About 86 women …

This study is for women under 75 who need heart bypass surgery for three blocked arteries. It compares two types of grafts for the second most important artery: a leg vein harvested with a special 'no-touch' technique versus a wrist artery. The goal is to see which graft stays op…

This study tests a procedure called a stellate ganglion block, where a numbing medicine is injected near nerves in the neck to calm severe, repeated episodes of dangerous heart rhythms (electrical storm). The trial will involve 64 adults with heart disease who have not responded …

This study tests whether a smartphone app that guides patients through a rapid recovery program (ERAS) can reduce time in the hospital after heart bypass surgery. About 480 adults in Brazil will use the app, which starts before surgery and continues for 30 days after discharge. T…

This study tests whether a non-invasive device called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung condition. Currently, diagnosis requires an invasive procedure called right heart catheterization. Researchers will compare E…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This study tests whether a 12-week resistance training program can improve physical function, quality of life, and heart-related biomarkers in people with heart failure who are on the waiting list for a heart transplant. Participants will be randomly assigned to either the exerci…

This study tests whether focused shock wave therapy can reduce pain and improve jaw function in people with temporomandibular disorders (TMD) of muscular origin. One hundred adults with moderate to severe jaw pain for at least 3 months will receive either shock wave therapy or a …

This study tests two treatments for vaginal dryness in women with Sjögren's disease: a fractional CO2 laser applied monthly for three months, and a topical promestriene cream used for six months. Sixty participants will be randomly assigned to one of the two groups. The goal is t…

This study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The main goal is to see if craving…

This study tests small hormone implants placed under the skin to relieve menopause symptoms like hot flashes, low mood, and sexual problems. It includes 140 women with natural menopause, early ovarian failure, or menopause from cervical cancer treatment. Researchers will check ho…

This study tests whether a stabilizing occlusal splint (a type of mouthguard) can reduce tinnitus (ringing in the ears) in people who also have temporomandibular joint (TMJ) disorder. Researchers will compare the real splint to a placebo splint in 63 adults over 4 months, measuri…

This study follows 50 adults who have had pulmonary endarterectomy surgery for chronic blood clots in the lungs. Researchers will measure walking ability, muscle strength, lung function, and frailty before and after surgery. The goal is to understand how recovery progresses and w…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study tests whether sending automatic WhatsApp reminders helps more women with gestational diabetes attend their postpartum glucose test. It also compares a newer one-hour blood sugar measurement to the standard two-hour test to see which catches prediabetes and diabetes ear…

This study compares two video laryngoscopes—the standard McGRATH™ MAC and the newer BESDATA BD-DF—for placing breathing tubes in infants during surgery. Researchers want to see if the BESDATA device works just as well on the first try and is more cost-effective. About 226 childre…

This study is creating and testing a questionnaire called SAVOIR to measure how much people with pulmonary arterial hypertension (PAH) understand about their condition. Up to 215 patients and expert judges will help ensure the questions are clear, relevant, and reliable. The goal…

This study looks at whether tiny particles released by cells into the blood, called extracellular vesicles, can help detect a type of heart disease called ATTR amyloidosis earlier. The disease often goes unnoticed until serious damage occurs. Researchers will compare these partic…

This study looks at how long it takes for people in Brazil to get a correct diagnosis of pulmonary arterial hypertension (PAH), a rare and serious lung disease. Researchers will review medical records of about 139 adults diagnosed in the last five years to find out what causes de…

This study looks at what happens when people with pulmonary arterial hypertension (PAH) switch from one medication (ambrisentan) to another (bosentan). Researchers will track 121 adults to see if their risk level, symptoms, and side effects change after the switch. The goal is to…