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Could a short, High-Dose drug course cure small pituitary tumors?

NCT ID NCT07463235

Recruiting now Disease control Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a higher dose of the drug cabergoline, taken for about 6 months, can achieve lasting remission in women with small prolactinomas (non-cancerous pituitary tumors that cause excess prolactin). 70 premenopausal women will be randomly assigned to either the high-dose short course or standard long-term low-dose treatment. The goal is to see if the high-dose approach leads to normal prolactin levels for at least a year after stopping the drug, potentially avoiding years of daily medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Cabergoline (a drug that lowers prolactin levels)
What this could lead to
If successful, this could offer a shorter, more effective treatment course for small prolactinomas, potentially allowing women to stop medication sooner without the tumor returning.
What could go wrong
This is a relatively small, early-phase trial (70 participants) and the high dose may cause more side effects. Remission may not be permanent, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hyperprolactinemia prolactin-producing pituitary gland adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROLACTIN EXCESS PROLACTINOMA

Contacts and locations

Locations

  • CPC

    RECRUITING

    Ponta Grossa, Brazil

  • HCFMUSP

    RECRUITING

    São Paulo, Brazil

  • HCPA

    COMPLETED

    Porto Alegre, Brazil

  • Hospital Moinhos de Vento

    RECRUITING

    Porto Alegre, Brazil

  • Sta Casa-RS

    RECRUITING

    Porto Alegre, Brazil

  • Sta Casa-SP

    RECRUITING

    São Paulo, Brazil

  • UFG

    RECRUITING

    Goiânia, Brazil

  • UFMG

    RECRUITING

    Belo Horizonte, Brazil

  • UFPE

    RECRUITING

    Recife, Brazil

  • UFPR

    RECRUITING

    Curitiba, Brazil

  • UFRJ

    RECRUITING

    Rio de Janeiro, Brazil

  • UNB

    RECRUITING

    Brasília, Brazil

  • USP-RP

    RECRUITING

    Ribeirão Preto, Brazil

  • Unesp

    RECRUITING

    Botucatu, Brazil

  • Unicamp

    RECRUITING

    Campinas, Brazil

  • Unifesp

    RECRUITING

    São Paulo, Brazil

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