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Blood particles may reveal hidden heart disease

NCT ID NCT07314268

Recruiting now Knowledge-focused Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether tiny particles released by cells into the blood, called extracellular vesicles, can help detect a type of heart disease called ATTR amyloidosis earlier. The disease often goes unnoticed until serious damage occurs. Researchers will compare these particles in 70 people with and without the condition, using blood tests and heart imaging, to see if they can serve as early warning signs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test for earlier detection of ATTR amyloid cardiomyopathy, potentially improving treatment timing and outcomes.
What could go wrong
This is an early observational study with only 70 participants. The findings may not translate into a reliable clinical test, and the biomarkers may not prove useful for diagnosis or prognosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial ATTRV30M amyloidosis disease familial amyloid neuropathy hereditary amyloidosis wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYLOIDOSIS CARDIAC AMYLOIDOSIS TRANSTHYRETIN AMYLOIDOSIS, HEREDITARY WILD TYPE ATTR AMYLOIDOSIS

Contacts and locations

Locations

  • Instituto do Coracao, HCFMUSP

    RECRUITING

    São Paulo, São Paulo, 05403000, Brazil

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