Can the MenB vaccine protect kids with rheumatic conditions?

NCT ID NCT07252804

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing the meningococcal B vaccine (Bexsero) in children and young adults aged 2 to 25 who have autoimmune rheumatic diseases like juvenile arthritis or lupus. Researchers want to see if the vaccine triggers a strong immune response and if it is safe, especially for those on immune-suppressing medications. Participants will receive two vaccine doses one month apart, with blood tests to measure protection over a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Meningococcal B vaccine (Bexsero)
What this could lead to: If successful, this could show that the meningococcal B vaccine is safe and effective for children with autoimmune rheumatic diseases, helping protect them from serious infection.
What could go wrong: This is a phase 4 study, so the vaccine is already approved. However, immune-suppressing treatments may reduce vaccine effectiveness, and the trial is relatively small (263 participants), so results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

juvenile dermatomyositis juvenile idiopathic arthritis pediatric systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE RHEUMATOLOGIC DISEASE

Contacts and locations

Locations

Rheumatology Division, Faculdade de Medicina da USP
RECRUITING

São Paulo, São Paulo, Brazil
University of São Paulo General Hospital
RECRUITING

São Paulo, São Paulo, Brazil

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