Shingles vaccine trial aims to protect vulnerable patients
NCT ID NCT05879419
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a strong immune response. The goal is to prevent shingles without worsening the underlying rheumatic condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Recombinant Herpes Zoster Vaccine (Shingrix)
- What this could lead to
- If successful, this could show that the Shingrix vaccine is safe and effective for people with autoimmune rheumatic diseases, reducing their high risk of shingles.
- What could go wrong
- This is an early-stage study in a specific patient group, and results may not apply to all. The vaccine could cause flares or have reduced effectiveness due to immunosuppression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rheumatology Division of Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, São Paulo, 05403-000, Brazil
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