Shingles vaccine trial aims to protect vulnerable patients

NCT ID NCT05879419

Ongoing Prevention Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a strong immune response. The goal is to prevent shingles without worsening the underlying rheumatic condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Recombinant Herpes Zoster Vaccine (Shingrix)

What this could lead to

If successful, this could show that the Shingrix vaccine is safe and effective for people with autoimmune rheumatic diseases, reducing their high risk of shingles.

What could go wrong

This is an early-stage study in a specific patient group, and results may not apply to all. The vaccine could cause flares or have reduced effectiveness due to immunosuppression.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SJOGREN'S SYNDROME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acquired idiopathic inflammatory myopathy ankylosing spondylitis Behcet disease dermatomyositis granulomatosis with polyangiitis juvenile dermatomyositis juvenile idiopathic arthritis myositis disease psoriatic arthritis rheumatoid arthritis Sjogren syndrome Spondylarthritis spondyloarthropathy systemic lupus erythematosus systemic sclerosis Systemic Vasculitis vasculitis herpes zoster prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BEHÇET DISEASE DERMATOMYOSITIS, JUVENILE IDIOPATHIC INFLAMMATORY MYOPATHIES JUVENILE IDIOPATHIC ARTHRITIS RHEUMATOID ARTHRITIS SJOGREN'S SYNDROME SPONDYLITIS, ANKYLOSING SPONDYLOARTHRITIS SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC SCLEROSIS VASCULITIS, SYSTEMIC

Contacts and locations

Show contact details

Locations

Rheumatology Division of Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo

São Paulo, São Paulo, 05403-000, Brazil