SJOGREN'S SYNDROME

This study tests a new treatment using specially engineered immune cells (CAR-T) to target and calm overactive immune cells in people with autoimmune diseases like lupus, scleroderma, and Sjogren's syndrome. About 20 adults aged 18 to 70 with active disease will receive either CD…

This early-stage study tests a new cell treatment called YTS109 in 18 adults with hard-to-treat autoimmune diseases like lupus and Sjogren's syndrome. The main goal is to check if the treatment is safe, and also to see if it helps control the disease. Participants receive a singl…

This study tests whether tofacitinib, a pill already approved for rheumatoid arthritis, is safe for people with Sjogren's disease. About 60 adults with mild-to-moderate Sjogren's will take the drug twice daily for 28 weeks. Researchers will monitor side effects and check for impr…

This early-stage study tests a new drug, CLN-978, given as a shot under the skin for people with active, moderate to severe Sjogren's disease. The main goal is to check safety and side effects, and it will also measure how the drug works in the body and affects immune cells. Abou…

This early-stage study tests a new drug, SAR448501/DR-0201, in 62 adults with lupus or rheumatoid arthritis. The goal is to find the safest and most effective dose by checking side effects and how the drug works in the body. Participants will be followed for about 13 months, and …

This study tests whether an online program that teaches better diet and self-care can reduce fatigue and improve quality of life for adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis. About 200 participants will u…

This study follows 300 people with Sjogren's disease (or symptoms) over several visits to learn how the condition starts and changes. Researchers collect saliva, blood, and eye tests, and ask about symptoms. The goal is to find clues for better treatments, not to test a new thera…

This study looks at whether generative AI can help doctors better diagnose complications of rheumatoid arthritis (RA), such as lung disease or heart problems. Researchers will use AI to analyze patient records and suggest possible complications, then see if doctors find these sug…

This study is creating a registry of 1,000 pregnant women with autoimmune diseases like lupus and rheumatoid arthritis. Researchers will track their health and pregnancy outcomes to identify risk factors and ways to improve care for both mothers and babies. The study does not tes…

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take blood samples and expose the cells to different ca…

This study is testing whether a special PET scan called FAPI PET/CT can see inflammation in people with Sjögren's syndrome, an autoimmune disease that causes dryness. Researchers will compare the scan results with blood tests and also look at scans from people with tumors. The go…