SJOGREN'S SYNDROME

This is an early-stage safety study testing a single infusion of YTS109 cells in 18 adults with severe autoimmune diseases that have not responded to standard treatments. The main goal is to check for side effects and see how the body handles the cells. Researchers will also look…

This early-stage study is testing a new drug called SAR448501 in adults with moderate-to-severe lupus or rheumatoid arthritis who haven't gotten enough relief from their current treatments. The main goal is to find safe dose levels and see how the drug behaves in the body. About …

This study is testing if a drug called tofacitinib, already used for rheumatoid arthritis, is safe and can help control the symptoms of Sjogren's Syndrome. About 60 adults with mild to moderate Sjogren's will take the pill twice a day for 28 weeks to see if it reduces their disea…

This early-stage study is testing whether a type of cell therapy called CAR-T, which is used to treat some cancers, can help people with serious autoimmune diseases like lupus, scleroderma, and vasculitis. The therapy involves collecting a patient's own immune cells, modifying th…

This early-stage study is testing the safety and side effects of an experimental drug called CLN-978 in people with active, moderate to severe Sjogren's disease. The drug is given as an injection under the skin. Researchers will enroll 36 participants to monitor for any adverse r…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study is testing a new type of PET scan to see if it can better show inflammation in people with Sjögren's syndrome, a condition that causes dry mouth and eyes. Researchers will compare the scan results in 60 people with Sjögren's to scans from people with cancer to see if t…

This study is testing whether an online wellness program can help people with conditions like rheumatoid arthritis and lupus feel less tired and improve their quality of life. Researchers will enroll 200 participants to try a 6-month online course focused on diet, gentle exercise…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases like rheumatoid arthritis and lupus. The goal is to help researchers better understand what causes these conditions and how they progress over time. …

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This National Institutes of Health study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect health information, saliva, blood, and tissue samples from people with these conditions (like Sjogren's syndrome), their fami…

This study aims to learn more about what causes Sjogren's disease and how it progresses over time. Researchers will follow about 300 people with Sjogren's or similar symptoms for up to 10 years, collecting health information and samples like blood and saliva. The goal is to gathe…

This study aims to understand how different compounds from the cannabis plant affect immune cells in a lab setting. Researchers will collect blood from 100 patients with chronic inflammatory diseases like rheumatoid arthritis and lupus. They will test various cannabis extracts on…