New drug CLN-978 tested for Sjogren's sufferers
NCT ID NCT07041099
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing a new drug called CLN-978 in 36 adults with active, moderate to severe Sjogren's disease. The main goal is to see if the drug is safe and tolerable, while also checking how it affects immune cells in the blood. Participants receive the drug as a shot under the skin.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CLN-978
What this could lead to
If successful, this could point toward a new treatment option for people with active, moderate to severe Sjogren's disease.
What could go wrong
This is an early phase 1 trial with only 36 participants, so it is primarily testing safety and dosing. It may not lead to an effective treatment, and side effects are unknown.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cullinan Investigative Site
RECRUITINGOrlando, Florida, 32808, United States
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Cullinan Investigative Site
RECRUITINGMemphis, Tennessee, 38103, United States
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Cullinan Investigative Site
RECRUITINGPlano, Texas, 75093, United States
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Cullinan Investigative Site
RECRUITINGWebster, Texas, 77598, United States
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Cullinan Investigative Site
RECRUITINGSalt Lake City, Utah, 84107, United States
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Cullinan Investigative Site
RECRUITINGBrest, 29609, France
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Cullinan Investigative Site
RECRUITINGLe Kremlin-Bicêtre, 94270, France
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Cullinan Investigative Site
RECRUITINGStrasbourg, 67098, France
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Cullinan Investigative Site
RECRUITINGErlangen, 91054, Germany
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Cullinan Investigative Site
RECRUITINGHanover, 30625, Germany
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Cullinan Investigative Site
RECRUITINGRoma, 00168, Italy