New drug CLN-978 tested for Sjogren's sufferers

NCT ID NCT07041099

Recruiting now Disease control Sponsor: Cullinan Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This early-stage trial is testing a new drug called CLN-978 in 36 adults with active, moderate to severe Sjogren's disease. The main goal is to see if the drug is safe and tolerable, while also checking how it affects immune cells in the blood. Participants receive the drug as a shot under the skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CLN-978
What this could lead to: If successful, this could point toward a new treatment option for people with active, moderate to severe Sjogren's disease.
What could go wrong: This is an early phase 1 trial with only 36 participants, so it is primarily testing safety and dosing. It may not lead to an effective treatment, and side effects are unknown.

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Conditions

The condition(s) this trial relates to.

Sjogren syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SJOGREN DISEASE SJOGREN'S SYNDROME SJÖGREN

Contacts and locations

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Locations

CHU Brest
RECRUITING

Brest, 29609, France
CHU Nantes
RECRUITING

Nantes, 44093, France
CHU St.-Étienne
RECRUITING

Saint-Priest-en-Jarez, 42270, France
CHU Strasbourg-Hautepierre
RECRUITING

Strasbourg, 67098, France
Fondazione Policlinico Universitario A Gemelli
RECRUITING

Roma, 00168, Italy

Contact Email: •••••@•••••
Hannover Medical School
RECRUITING

Hanover, 30625, Germany
Hopitaux Universitaires Paris-Sud
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Intermountain
RECRUITING

Salt Lake City, Utah, 84143, United States
New York University
RECRUITING

Brooklyn, New York, 11201, United States
Omega Research
RECRUITING

Orlando, Florida, 32808, United States
Regional One
RECRUITING

Memphis, Tennessee, 38103, United States
Stryde Research
RECRUITING

Plano, Texas, 75093, United States
Tranquil Research
RECRUITING

Webster, Texas, 77598, United States
University Hospital Erlangen
RECRUITING

Erlangen, 91054, Germany

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