Machine perfusion may keep livers healthier for transplant
NCT ID NCT07595627
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two methods of preserving livers from deceased donors before transplant: a machine that pumps oxygenated cold fluid through the liver (hypothermic machine perfusion) versus the standard ice-cooled storage. Forty adult liver transplant patients will be randomly assigned to receive a liver preserved by one of these methods. Researchers will track early liver function, complications, and recovery over one year to see if the machine method reduces injury and improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hypothermic machine perfusion device
- What this could lead to
- If successful, this could improve liver transplant outcomes by reducing early graft injury and complications.
- What could go wrong
- This is a small, early-stage study with only 40 participants. The device may not show significant benefit over standard cold storage, and results may not apply to all transplant settings.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
São Paulo, São Paulo, 05403-000, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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