Liver failure

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This study tests whether giving a higher dose of albumin (a protein) to people with advanced liver cirrhosis and fluid buildup (ascites) can reduce the need for fluid drainage procedures and prevent complications. About 100 adults with hard-to-treat ascites will receive either hi…

This study is testing a telemedicine program called Vet-CALD for Veterans with advanced liver disease. The program pairs patients with a nurse care counselor who helps them understand their illness, set personal health goals, and coordinate care between their regular doctors and …

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This study tests whether a blood-filtering device called DPMAS can help people with acute-on-chronic liver failure, a life-threatening condition. The device removes toxins and inflammatory substances from the blood, which may improve immune function and survival. Forty intensive …

This early-stage trial is testing the drug sacituzumab govitecan in 30 people with advanced solid tumors who also have moderate liver impairment. The main goal is to find a safe starting dose by monitoring side effects and how the drug moves through the body. Participants receive…

This pilot study tests whether giving a combination of two growth factors (G-CSF and darbepoetin) in single or repeated cycles can improve immune function in people with early decompensated cirrhosis. Sixty participants will be randomly assigned to receive either the growth facto…

This study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of…

This study tests whether a home monitoring system called CirrhoCare can help people with decompensated cirrhosis avoid unplanned hospital visits. Participants use an Apple Watch, iPhone app, and Bluetooth devices to track their health at home. The trial will compare this approach…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This early-phase trial is testing a new bioartificial liver device that uses liver cells grown from stem cells. It will be given to 12 people with liver failure or small-for-size syndrome. The main goal is to see if the treatment is safe and tolerable, while also checking for any…

This early study tests whether using mesenchymal stem cells in a blood purification device is safe and can help adults with liver failure. Ten participants will receive the treatment alongside standard care. Researchers will track survival at 28 days and check for side effects. T…

This study tests whether a machine that keeps donated livers working outside the body can help doctors safely use livers that were previously considered too risky for transplant. About 186 adults on the liver transplant waiting list will be randomly assigned to either receive a s…

This study tests whether text message reminders and a smart pillbox can help teenagers and young adults take their daily anti-rejection medicine on time after a kidney or liver transplant. About 65 participants aged 13-25 will use an electronic pillbox that tracks when they take …

This study tests whether a daily nutritional supplement containing resveratrol, quercetin, taurine, inulin, and whey protein can improve liver function and quality of life in adults with liver disease from chronic hepatitis C. Over 12 weeks, 26 participants will take either the s…

This study tests whether a donor stem cell infusion can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. Twelve adults who had a liver transplant from a matched living donor at least one year ago will receive the infusion after a mild …

This study compares a new method using ROTEM (a rapid blood clotting test) to standard care for deciding whether to give blood products before high-risk procedures in patients with decompensated liver cirrhosis. The goal is to see if the ROTEM-guided approach reduces the number o…

This pilot study tests whether adding the statin atorvastatin to a standard beta blocker can help people with decompensated cirrhosis, a severe form of liver disease. Fifty participants will receive either atorvastatin plus their usual beta blocker or a placebo plus beta blocker,…

This study tests whether empagliflozin, a diabetes drug, can help people with cirrhosis and ascites (fluid buildup in the belly) get rid of excess salt and water. About 20 adults on stable diuretics will take the drug or a placebo for 14 days. Researchers will measure changes in …

This phase 3 trial tests whether giving low-dose arginine vasopressin during liver transplant surgery can prevent acute kidney injury, a common complication. Researchers will compare vasopressin to the standard drug norepinephrine in 304 adults. The goal is to see if vasopressin …

This study tests whether a biomarker can predict which people with advanced liver cirrhosis and fluid buildup (ascites) will benefit from regular albumin infusions. About 240 adults will receive either albumin or a placebo every 10 days for 6 months. The goal is to see if the bio…

This study tests a new treatment called RTX001 for people with severe liver scarring (cirrhosis) that has led to complications. RTX001 uses the patient's own immune cells, modified in a lab to reduce inflammation and scarring. The trial will enroll 30 adults to check if the thera…

This study tests a combined blood-filtering system (DPMAS and plasma exchange) in 25 adults with acute-on-chronic liver failure who are either waiting for a liver transplant or not eligible for one. The goal is to see if this artificial liver support can keep patients alive witho…

This study tests whether a standard volume of plasma exchange (blood filtering) works as well as a high volume in children aged 3 to 18 with acute liver failure. The goal is to see which approach helps more children survive without needing a liver transplant by day 21. Forty part…

This study tests if transplanting a piece of abdominal wall (the muscle and tissue covering the belly) can safely repair large defects, like hernias or injuries. It can be done alone or with another organ transplant, like a kidney or liver. Only 5 adults aged 18-65 are being enro…

This study follows 30 adults with end-stage liver cirrhosis who receive a living-donor liver transplant. Researchers track bleeding and clotting complications to identify risk factors and improve prevention strategies. The goal is to make liver transplants safer in the early reco…

This study tests if a drug called darbepoetin can lower the need for blood transfusions during liver transplant surgery. About 140 adults on the liver transplant waiting list with low hemoglobin will receive either the drug or a placebo. The goal is to see if the drug safely redu…

This study tests whether a steroid drug (methylprednisolone) can help people with severe liver injury caused by medications. The trial includes 232 adults with high bilirubin levels. Participants receive either steroids plus standard care or standard care alone, and doctors track…

This study tests whether a medicine called tranexamic acid can reduce blood loss during adult liver transplant surgery. About 1,546 people will be randomly assigned to receive either the drug or a placebo. The main goal is to see if the drug works better than placebo at controlli…

This study looks at whether a procedure called TIPS, which creates a bypass in the liver, can help people with advanced cirrhosis achieve 'recompensation' — meaning the liver partially recovers and complications ease. Researchers will follow 250 patients for one year after TIPS t…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This Phase 2 trial is testing an experimental drug called F573 in 97 people with acute liver failure or acute-on-chronic liver failure. Participants receive daily injections of F573 or a placebo for 7 days. The main goal is to check safety and side effects, while also looking at …

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety cri…

This early-stage trial is testing whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with serious liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut metabolites. Resea…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during liver transplant surgery. The device measures blood clotting in real time. Researchers hope it will reduce bleeding and the amount of blood products needed. The…

This phase 3 trial tests a new solution called Custodiol-N for preserving donated kidneys, livers, and pancreases before transplant. About 362 recipients will be randomly assigned to receive organs stored in either Custodiol-N or the standard Custodiol solution. The goal is to se…

This study aims to create a simple blood test to find liver cancer at an early, more treatable stage. Researchers will analyze genetic material in the blood of 600 adults, including those with liver cancer, chronic liver disease, and healthy volunteers. The goal is to improve ear…

This study tests a new endoscopic ultrasound method (EUS-SWQ) to measure liver stiffness and diagnose liver fibrosis (scarring) in people with chronic liver disease. Researchers will compare EUS-SWQ results with standard liver biopsy and FibroScan in 65 adults. The goal is to see…

This study is testing a new, non-invasive ultrasound device called the Hepatoscope to screen for liver scarring (fibrosis) and fatty liver in people at risk. Researchers will enroll 200 patients with risk factors like diabetes or elevated liver enzymes. Those with high stiffness …

This study is testing whether measuring spleen stiffness with a non-invasive scan can accurately diagnose and monitor portal hypertension in people with advanced chronic liver disease. Researchers will enroll 200 participants and track them over time to see if this simple test ca…

This pilot study tests a new cognitive test using building blocks to quickly screen for minimal hepatic encephalopathy (MHE), a subtle brain complication in people with liver disease. Researchers will compare the test's accuracy against standard methods in 100 adults with liver f…

This study is testing whether a special MRI scan called 3D-MRE can accurately detect high blood pressure in the liver (portal hypertension) caused by cirrhosis or advanced liver disease. Currently, doctors use an invasive catheter procedure (HVPG) to measure this pressure. The st…

This study is testing whether special ultrasound scans can accurately detect liver damage in children without needing a needle biopsy. Researchers will compare these scans to standard biopsy results in 550 children with various liver conditions. If the scans prove reliable, they …

This study is testing a blood test called hepatomiR to see if it can predict when people with chronic liver disease will develop serious complications like fluid buildup in the belly, bleeding from the esophagus, or confusion from liver failure. Researchers will follow 156 outpat…

This study tests if drinking a carbohydrate beverage before liver transplant surgery helps patients recover more quickly and spend fewer days in the hospital. About 434 adults receiving a liver transplant will be randomly assigned to drink either the carbohydrate drink or a place…

This study tests a home monitoring program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly check-ins to boost activity and manage symptoms. The goal is to see if this approach improves qual…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study investigates whether measuring the thickness of the carotid artery (a major artery in the neck) before surgery can help predict blood pressure swings and complications during liver transplant operations. Researchers will measure carotid artery thickness using a simple,…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with normal liver function. It involves 32 adults and is for research only, not to treat any condition. The goal is to understand…

This study looks at a heart condition called cirrhotic cardiomyopathy that can affect people with advanced liver disease (cirrhosis). Researchers want to learn how common it is, what increases the risk, and whether bile acids in the blood play a role. About 440 adults with decomp…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This early-stage study looks at how a new drug, INCB123667, behaves in the bodies of 16 adults with moderate or severe liver disease. Researchers will measure drug levels and watch for side effects. The goal is to gather safety information, not to treat the liver condition.

This early-stage study is testing how the drug BMS-986435 behaves in the body and whether it is safe for people with mild to moderate liver problems compared to those with healthy livers. 24 adults will receive a single dose, and researchers will measure drug levels and monitor f…

This early-phase study looks at how a single dose of the drug inavolisib behaves in people with moderate or severe liver impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and check for side effects. The goal is to understand if liver pro…

This study looks at how a single dose of the experimental drug BI 1291583 behaves in the blood of people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults aged 18–80 will take part, divided into groups based o…

This early-stage study is testing a single dose of the drug eloralintide in 36 people with different levels of liver function—from healthy to severely impaired. Researchers want to see how the body absorbs and processes the drug and whether it causes side effects. The goal is to …

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This early-stage study looks at how the liver handles two experimental drugs, AZD9550 and AZD6234, in people with moderate to severe liver problems compared to healthy volunteers. About 28 adults will receive a single injection of one drug. The goal is to see if liver impairment …

This early-stage study by Pfizer looks at how different levels of liver function affect the processing of a new drug called PF-07328948. About 26 adults with and without liver impairment will take a single tablet and stay at the clinic for 6 days for monitoring and blood tests. T…

This study looks at how inflammation and liver repair differ in people with alcoholic hepatitis versus those with alcoholic cirrhosis or healthy livers. Researchers will collect blood, liver tissue, and fluid samples from 450 participants. The goal is to better understand what dr…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

This early-stage study is recruiting 44 adults aged 18 to 80, including both healthy people and those with liver problems. All participants will take a single tablet of the drug BI 3000202. Researchers will measure how the drug moves through the body and check for side effects ov…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study follows 60 adults with cirrhosis who are waiting for a liver transplant but do not have diabetes. Researchers want to see if tests like glucose monitoring, oral glucose tolerance tests, and wrist activity trackers can predict who will develop diabetes after the transpl…

This study follows 275 infants who received a liver transplant to see how they grow over time. Researchers want to understand growth patterns and find ways to improve care. The study is observational, meaning no new treatment is being tested.

This early-stage study is testing how the drug radiprodil behaves in people with mild, moderate, or severe liver problems compared to healthy adults. About 40 participants will receive a single dose and be monitored for about a week. The goal is to see if liver impairment affects…

This study is looking for new blood markers that could show how much scarring (fibrosis) is in the liver of people with chronic liver disease. Researchers will compare these markers to current tests like FibroScan and liver biopsy. The goal is to find a more accurate and less inv…

This early-stage study is testing an investigational drug called PF-08653944 in 26 adults, some with healthy livers and others with mild to severe liver impairment. Researchers want to see how liver function affects the way the body processes the drug and whether it is safe. Part…

This study from Mayo Clinic aims to understand the individual and social reasons why some patients with end-stage liver disease are not listed for or do not receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list, who receives a transpl…

This study looks at whether the amount of healthy liver removed during surgery can predict liver failure afterward. Researchers will create a risk model based on 1,600 patients who had liver surgery for cancer. The goal is to help doctors identify high-risk patients before surger…

This study looks at how the body handles a single dose of the drug vepdegestrant in people with moderate to severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take one pill and stay at the clinic for 11 days. The goal is to see if liver function a…

This study will follow 1,200 liver transplant patients in France to understand why some people bleed heavily during surgery while others don't. Researchers will use advanced methods like machine learning to build better prediction tools. The goal is to help doctors manage bleedin…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This early-stage study is testing a single dose of an experimental drug called EDG-7500 in 32 adults. Some have mild or moderate liver problems, while others have normal liver function. Researchers want to see how the drug moves through the body and if it is safe in people with d…

This study looks at how the drug MK-1084 (calderasib) moves through the body in people with and without liver problems. Researchers will measure drug levels in the blood and check for side effects. About 58 adults will take a single dose and be monitored. The goal is to understan…

This study is creating a digital tool to help teenagers and young adults (ages 14-20) who have had or are waiting for a liver transplant as they move from pediatric to adult care. The tool helps patients and doctors track medication use and well-being from home, reducing hospital…

This study looks at how frailty, muscle loss, nutrition, and mental health affect people waiting for a liver transplant. Researchers will test physical strength, walking ability, and daily living skills, and also check nutrition and psychological well-being. The goal is to see wh…

This study collects blood and tissue samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse tumors, to study these diseases and test new treatments. The goal is to improve unders…

This study is testing a new single probe for FibroScan, a device that measures liver stiffness to assess disease. Researchers want to see if one probe can work as well as the current two-probe system. About 309 adults with chronic liver disease will take part across France and Ho…

This study is testing whether a simple neck ultrasound can predict dangerous drops in blood pressure after anesthesia in adults with chronic liver disease. Researchers will measure blood flow in the carotid artery before and after anesthesia in 35 patients. If the method works, i…

This study looks at how well people who have had a liver transplant can move and function. Researchers will use a 30-second test where patients lie down and sit up as many times as they can. The goal is to see how this test relates to muscle strength, exercise ability, and overal…

This study looks at how mild and moderate liver problems change the way the body handles a single dose of the drug tasurgratinib. Researchers will compare 18 people with stable liver impairment to healthy volunteers matched by age, weight, race, and gender. The goal is to underst…

This study looks at whether a tool called the HScore can accurately diagnose hemophagocytic lymphohistiocytosis (HLH) in intensive care patients with liver failure or cirrhosis. Researchers will review medical records of 100 adults admitted to one hospital over ten years who had …

This study looks at whether a special MRI scan that measures muscle health and frailty can predict death or the need for a liver transplant in people with liver disease. Researchers will follow 1,200 patients who are already getting an MRI for routine care. The goal is to see if …

This early-stage study is testing how the drug TS-172 behaves in the bodies of people with mild or moderate liver impairment. Researchers will measure drug levels in the blood to see if liver function affects how the drug is processed. The study involves 24 Japanese adults and is…

This study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…

This study is testing two scoring methods (PLEASE and M10S20) to see if they can better predict serious liver events, liver cancer, and death in 600 people with advanced chronic liver disease. Participants are randomly assigned to standard care or a risk-based monitoring schedule…

This study looks at how the body handles a single dose of the cancer drug olverembatinib in people with normal vs. impaired liver function. Researchers will measure drug levels and safety in 48 adults. The goal is to understand if liver problems require dose adjustments.

This study looks at how a drug called LY3537031 moves through the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to understand how liver function affects drug…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study tests a special follow-up program called the Transitional Liver Clinic (TLC) for people with advanced liver disease after they leave the hospital. The program includes extra phone calls or video visits and more attention from liver specialists. The goal is to see if th…

This study looks at the social and economic challenges faced by people with chronic liver disease, like trouble paying for food or housing. Researchers will survey 400 patients and their doctors at Indiana University Health to find out what needs are most common and how patients …

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This study looks at medical records from 15,000 people to see how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are linked to other health problems. Researchers will track new cases of liver cancer and complications over time. The goal is to better understan…

This registry follows 250 patients with decompensated liver cirrhosis who receive a TIPS procedure, a shunt placed in the liver to reduce pressure. Researchers will track survival, brain function, nutrition, and quality of life over one year. The goal is to identify which patient…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …