New study seeks safe dose of cancer drug for patients with liver issues
NCT ID NCT04617522
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing the drug sacituzumab govitecan in 30 people with advanced solid tumors who also have moderate liver impairment. The main goal is to find a safe starting dose by monitoring side effects and how the drug moves through the body. Participants receive the drug intravenously, and the study will track any serious reactions or lab changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sacituzumab govitecan (a drug that combines an antibody with chemotherapy to target cancer cells)
- What this could lead to
- If successful, this study could help doctors find a safe starting dose of sacituzumab govitecan for patients with advanced cancer and liver problems, potentially expanding treatment options.
- What could go wrong
- This is a very early phase 1 trial with only 30 participants, so results may not apply to everyone. The drug may still cause serious side effects, especially in people with liver impairment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Leon Berard
RECRUITINGLyon, 69373, France
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Christiana Care Health Services
RECRUITINGNewark, Delaware, 19713, United States
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Hospital Universitario Virgen del Rocío
RECRUITINGSeville, 41013, Spain
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Institut Bergonie Medical Oncology
RECRUITINGBordeaux, 33000, France
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Institut Català d'Oncologia - L'Hospitalet de Llobregat
RECRUITINGBarcelona, 08908, Spain
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Institut de Cancerologie de l'Ouest (ICO) - Saint-Herblain
RECRUITINGSaint-Herblain, France
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Instituto Europeo di Oncologia
RECRUITINGMilan, 20141, Italy
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Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
RECRUITINGNaples, 80131, Italy
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NEXT Austin
WITHDRAWNAustin, Texas, 78758, United States
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
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Oncology Consultants, P.A.
RECRUITINGHouston, Texas, 77030, United States
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Pacific Shores Medical Group
SUSPENDEDLong Beach, California, 90813, United States
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Texas Liver Institute
RECRUITINGSan Antonio, Texas, 78215, United States
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The University of Texas M.D. Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Maryland
RECRUITINGBaltimore, Maryland, 21201, United States
More trials for these conditions
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- Massive UK study tracks cancer after organ transplants
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