Could a radiation and antibody combo free liver transplant patients from daily pills?
NCT ID NCT07634562
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether a combination of total lymphoid irradiation (a type of radiation) and anti-thymocyte globulin (an antibody drug) can help liver transplant recipients safely stop taking immunosuppressive drugs. The study will enroll 12 adults receiving a liver transplant at Stanford University. The goal is to see if this approach can induce 'operational tolerance,' meaning the body accepts the new liver without needing long-term medication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Anti-Thymocyte Globulin (ATG) and Total Lymphoid Irradiation (TLI)
- What this could lead to
- If successful, this could allow liver transplant recipients to stop taking lifelong immunosuppressive drugs, reducing side effects and improving quality of life.
- What could go wrong
- This is a very early, small trial with only 12 participants, so results may not apply widely. The conditioning regimen carries risks like infection, bone marrow suppression, and graft rejection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Stanford University
Stanford, California, 94305, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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