Blood filtering showdown: can lower volume save young livers?

NCT ID NCT06831643

Recruiting now Disease control Sponsor: Institute of Liver and Biliary Sciences, India Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a standard volume of plasma exchange (blood filtering) works as well as a high volume in children aged 3 to 18 with acute liver failure. The goal is to see which approach helps more children survive without needing a liver transplant by day 21. Forty participants will be randomly assigned to one of the two treatments, and researchers will also monitor side effects and recovery of liver function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: therapeutic plasma exchange (blood filtering)
What this could lead to: If successful, this could show that a lower volume of plasma exchange is just as effective as high volume, reducing risks and strain on blood bank resources for children with acute liver failure.
What could go wrong: This is a small pilot study with only 40 children, so results may not be definitive. Both procedures carry risks like transfusion reactions or infections, and the trial may not prove one method is clearly better.

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Conditions

The condition(s) this trial relates to.

acute liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LIVER FAILURE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Institute of Liver & Biliary Sciences
RECRUITING

New Delhi, National Capital Territory of Delhi, 110070, India

Contact Phone: •••-•••-•••• Email: •••••@•••••

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