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Scientists hunt for clues in body fluids to predict liver failure outcomes

NCT ID NCT02833064

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study aims to find biological markers in blood, urine, stool, and breath that can predict how patients with acute liver injury or failure will fare. Researchers will collect samples daily for up to seven days from 200 participants, and a small group will also undergo MRI scans. The goal is to better understand the disease and improve care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict complications and outcomes in liver failure, guiding better treatment decisions.
What could go wrong
This is an observational study, not a treatment trial. It may not identify clear biomarkers, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2016

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

1. Acute liver failure 2. Acute liver injury 3. Acute on chronic hepatic failure 4. Stable cirrhotics 5. Non-cirrhotic liver disease

Ages

16 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * acute liver injury (newly deranged liver function tests (LFTs) and coagulopathy with International Normalized Ratio (INR) \>1.5 in absence of chronic liver disease) * acute liver failure ( as above, plus hepatic encephalopathy) * acute on chronic liver failure (worsening of LFTS and development of at least 1 organ failure in patient with cirrhosis) * stable cirrhosis * non-cirrhotic liver disease Exclusion Criteria: * refusal of consent * withdrawal of consent

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Conditions

The condition(s) this trial relates to.

acute liver failure cirrhosis of liver liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute liver failure Acute liver injury Acute on chronic hepatic failure

More trials for these conditions

Other studies related to the condition(s) this trial covers.