University Of Edinburgh

This large trial is testing whether existing, approved drugs can slow down the progression of motor neuron disease (MND), also known as ALS. It will involve about 1,150 participants and uses a flexible design where ineffective drugs are dropped and new ones can be added over time…

This study is testing a new system that uses healthcare data and a smartphone app to try to predict asthma attacks in children and young people aged 5-17. The goal is to identify kids at high risk and contact their doctors or families early to prevent the attack from happening. A…

This study investigates how weight loss can potentially reverse type 2 diabetes by reducing fat buildup in the pancreas. Researchers will follow 104 overweight participants with different diabetes stages as they complete an 8-12 week low-calorie diet program. The goal is to under…

This study offers a potential way to preserve fertility for young boys who must undergo cancer treatments that are very likely to cause infertility. Doctors will collect and freeze a small piece of testicular tissue from these boys before their cancer therapy begins. The frozen t…

This study is testing if a simple, on-the-spot blood test given 2 to 4 days after starting an early abortion can reliably show if the treatment worked, instead of the standard 7-day wait. It aims to make the follow-up process simpler and more convenient for patients. The study wi…

This study is testing if two existing blood pressure medications can improve blood vessel health and reduce the risk of heart disease in people with large vessel vasculitis (LVV). Sixty participants, including people with LVV in remission and healthy volunteers, will take the dru…

This study is testing a new, short conversation to help emergency room patients who had chest pain but not a heart attack. These patients are at higher future risk but often get sent home without clear information. Researchers will give patients their specific heart test result a…

This study is testing if a smartphone app can help detect and monitor brain diseases like dementia, Parkinson's, multiple sclerosis, and motor neuron disease by analyzing changes in a person's speech. Researchers will compare speech recordings from 150 people with these condition…

This study is testing a new type of heart scan to see if it can detect blood clots inside the heart's arteries. The goal is to better understand what caused a patient's heart attack, as not all heart attacks are caused by clots. Researchers will enroll 80 people who recently had …

This study is testing if a special heart scan can better identify which patients waiting for a kidney transplant are at the highest risk of a heart attack or stroke. It will involve 332 patients on the transplant waiting list. The goal is to see if this scan can improve the curre…

This research is testing a new, simple bedside device that can diagnose methanol poisoning from a single drop of blood. Methanol poisoning is dangerous and hard to diagnose, often leading to delayed treatment. The study aims to see if this quick test helps doctors start the right…

This study aims to better understand and detect early heart scarring (fibrosis) in three specific heart conditions: aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans and blood tests on 180 participants to see if they c…

This study is testing if wearable sensors can help spot early warning signs when a patient's health starts to decline after major surgery. Over 1300 patients in eight countries will wear chest and finger sensors for up to 10 days to record their heart rate and oxygen levels. The …

This study is testing a blood test to help doctors monitor throat cancer. The test looks for tiny pieces of cancer DNA in the blood to see how well treatment is working and to spot if the cancer comes back early. Researchers are enrolling 250 people with throat cancer, including …

This study aims to find out if damage to tiny blood vessels in the brain, which can cause stroke and dementia, also causes similar leakage in the blood vessels at the back of the eye. Researchers will give 40 participants with known small vessel disease a special eye scan that us…

This study aims to understand where blood clots come from and what role they play in causing different types of stroke. Researchers will use a new imaging tracer, called 18F-GP1, to take pictures of active blood clots in the brains of 120 adults who recently had a stroke. The goa…

This study aims to learn what causes aortic stenosis (a stiffening heart valve) to progress and what happens after valve replacement. It will follow 300 people, including patients with mild to severe disease and healthy volunteers, for four years. Researchers will use advanced he…

This study aims to see if a new type of full-body scan (PET scan) can better detect active disease and predict future heart disease risk in people with ANCA-associated vasculitis (AAV), a serious autoimmune condition. Researchers will compare scan results from about 120 people—so…

This study is exploring whether a quick, non-invasive eye scan can detect body-wide inflammation in people with endometriosis. Researchers will compare detailed images of the back of the eye from 100 women—some with endometriosis and some without—to see if the scans show measurab…

This study aims to create a detailed health profile of 100 adults admitted to a general psychiatric hospital. Researchers will use questionnaires and medical records to measure the severity of mental illness, physical health problems, and treatment history. The goal is to see how…

This study aims to improve how doctors are trained to perform bronchoscopies, a procedure to examine the lungs. Researchers will collect videos from 300 patients' procedures and have up to 20 doctors wear special sensor gloves to record their hand movements. The goal is to use th…

This large UK study aims to gather detailed information to improve the diagnosis and future treatment of endometriosis. It will follow 1000 women with the condition for two years, collecting data on their symptoms, lifestyle, and biological samples. The goal is to find patterns a…

This study aims to better understand takotsubo cardiomyopathy, often called 'broken heart syndrome,' which causes sudden heart weakness usually triggered by stress. Researchers will use a special MRI dye called manganese to see how different heart medications affect the heart mus…

This study aims to understand how common sleep-disordered breathing is in children with cerebral palsy (CP) across the UK and how many use breathing support devices at night. Researchers will survey hospitals for one year to count cases and identify what helps or prevents familie…

This study aims to better understand cancer cachexia—a condition where patients lose muscle and weight, which can worsen outcomes even for those undergoing potentially curative surgery. Researchers will track 200 UK patients with certain digestive cancers, along with a small comp…

This study is testing a special type of MRI scan to see if it can help doctors predict which patients with kidney disease are most likely to develop serious heart problems. Researchers will scan the hearts and kidneys of 120 people with different kidney conditions, including rece…

This study aims to define a new concept called 'visual frailty' and create a tool to measure it. Researchers will gather information from 20 Scottish adults aged 60+ with advanced age-related macular degeneration (AMD). They will look at vision, reading ability, daily function, m…

This study aims to understand the real-life experiences of children with cerebral palsy (CP) who have sleep breathing problems, their families, and their healthcare teams. Researchers will conduct interviews with about 20 participants to learn about the challenges and successes o…

This Scottish study follows 200 kidney transplant patients to see if certain substances in their urine can predict transplant rejection. Researchers will collect urine samples during routine check-ups to identify early warning signs. The goal is to find better ways to monitor tra…

This study aims to better understand the processes that cause artery blockages in people with leg pain from poor circulation. Researchers will perform full-body scans on 100 participants to see how inflammation and calcification in leg arteries relate to plaque in other arteries,…

This study aims to test a new imaging method to detect and track bowel scarring (fibrosis) in people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see if they can spot early scarring and monitor its activity over time. The goal is to create a tool t…

This study aims to understand how blood pressure and artery stiffness change between day and night in people at high risk for heart disease, including those with kidney problems. Researchers will measure these patterns in 120 participants over 24 hours on two separate occasions. …

This study aims to better understand the experiences of people living with Takayasu arteritis (TAK) and how doctors manage the condition. It involves separate online surveys for UK-based patients with TAK and the physicians who treat them. The goal is to learn about daily challen…