University Of Edinburgh

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't have symptoms yet. Doctors use MRI scans to find early heart muscle scarring, which can predict future problems. Participants with scarring are randomly assigned to either early valve replac…

This study tests whether MitoQ, a supplement that protects cell powerhouses (mitochondria), can help people with moderate ulcerative colitis (UC) flares. About 79 adults with active UC will take either MitoQ or a placebo daily for 24 weeks, alongside standard steroid treatment. T…

This study aimed to see if adding MitoQ (an antioxidant supplement) to standard treatment helps control inflammation in children aged 6–17 with mild-to-moderate ulcerative colitis. Participants would have taken MitoQ or a placebo daily for 24 weeks alongside their usual medicatio…

This study tests a computer tool called CoDE-HF that helps doctors quickly diagnose acute heart failure, a sudden inability of the heart to pump blood. The tool combines a blood test (NT-proBNP) with patient information to give a probability of heart failure. Researchers will stu…

This study aimed to see if a soft membrane pressed onto the eye (corneal impression membrane) is better than the standard scraping method for diagnosing microbial keratitis, a serious eye infection. The membrane is designed to be more comfortable and may detect more germs. The st…

This study follows people who carry a gene mutation that puts them at high risk for Paget's disease of the bone. Researchers want to see if a single dose of zoledronic acid (a bone-strengthening drug) can prevent or delay the disease compared to a placebo. Participants will be mo…

This study compares using a CT scan of the heart arteries versus standard risk scores to guide treatment in people aged 40-70 with risk factors like high blood pressure, diabetes, or smoking. The goal is to see if the CT scan approach reduces deaths from heart disease and non-fat…

This study looks at whether giving blood transfusions to patients who are anemic after leaving the intensive care unit (ICU) can help them feel less tired and recover better. About 346 adults will be randomly assigned to either the usual care (transfusions only if very needed) or…

This study looks at whether people with possible angina can get a full risk assessment within one working day. About 500 adults will fill out a health questionnaire at home, have an ECG, and get a blood test. The goal is to see if this fast approach is possible and can help sort …

This observational study uses a safe, non-invasive light-based monitor to measure oxygen levels in the brains of two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers …

This study looks at 400 people already in a larger heart scan trial to see if being in the study helps them eat better, exercise more, or quit smoking. Researchers will check diet, activity, and habits at the start and again after 6 months. For those who get a CT scan, the team w…

This study looks at people who came to the hospital with chest pain but were told they did not have a heart attack. Even though they are sent home, some may still have hidden heart disease that puts them at risk for a future heart attack. The study uses a special heart scan (CT c…

This study surveys general dentists in two UK regions to understand why silver diamine fluoride (SDF) — a quick, needle-free liquid that stops tooth decay — is not widely used for children. Researchers aim to identify barriers like lack of training or cost, so more kids can benef…

This study follows 440 people with relapsing-remitting multiple sclerosis for 5 to 10 years after their diagnosis. Researchers will use brain scans and other tests to see how the disease changes over time and what factors predict its course. No new treatments are being tested—the…

This study aimed to see if certain genes that make people more prone to bleeding could cause a stool test for colon cancer to show a false-positive result. Researchers planned to collect saliva samples from people who had a positive stool test but a normal colonoscopy, and compar…

This study tests a new device that measures troponin from a finger-prick blood sample in about 10 minutes, instead of the usual 2-hour lab test. Researchers want to see if this faster test can help diagnose heart attacks earlier and reassure patients who are not having one. About…

This study follows 124 golfers who had hip, knee, or shoulder replacement surgery to see how many return to golf and how long it takes. Researchers will also track changes in handicap, mobility, and joint pain over one year. The goal is to give patients and doctors clear informat…

This study looks at whether a future large trial on treatments for brain hemorrhage (bleeding in the brain) is acceptable to patients, their families, and doctors. It involves 169 adults who had a stroke from a brain bleed. Participants watch a video, read information, give conse…

This study looks at how family doctors in Latin America can provide better palliative care—care that focuses on comfort and quality of life for people with serious illnesses. Researchers will work with 30 to 50 healthcare professionals across the region to understand what helps o…

This study compares two ways to learn laparoscopic (keyhole) surgery: an AI-powered game-based simulator versus a standard box trainer. About 157 medical students and doctors with little or some experience will be randomly assigned to one method. The goal is to see if the AI game…

This study looks at whether genetic testing can predict who will develop Paget's disease of the bone, a condition that can cause pain and deformity. Researchers will test 135 people aged 45 and older who have a parent or sibling with Paget's but don't have it themselves. Particip…

This study aims to classify people with atrial fibrillation (AFib) into groups based on the electrical patterns in their hearts, using computer simulations. Researchers hope this will lead to more targeted treatments. About 91 adults with AFib will have their heart activity measu…