University Of Edinburgh

This study tests whether MitoQ, a supplement that protects cell batteries (mitochondria), can help people with moderate ulcerative colitis (UC) flare-ups. About 79 adults will take either MitoQ or a placebo daily for 24 weeks, alongside standard steroid treatment. The goal is to …

This study aimed to test whether MitoQ, a dietary supplement with antioxidant properties, could help control inflammation in children aged 6–17 with mild-to-moderate ulcerative colitis. Participants would have taken MitoQ or a placebo daily for 24 weeks alongside their usual medi…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Doctors usually wait until symptoms appear before replacing the valve, but by then the heart may already be damaged. The researchers use MRI scans to find hidden scarring …

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This study aimed to see if a soft membrane placed on the eye could diagnose microbial keratitis (a serious eye infection) better and more comfortably than the standard scrape test. Researchers planned to compare the two methods in adults with new corneal infections. However, the …

Acute heart failure is a life-threatening condition where the heart suddenly can't pump blood, but its symptoms often mimic other illnesses, causing delays in diagnosis. Researchers developed a computer algorithm called CoDE-HF that combines a blood test (NT-proBNP) with patient …

This study follows people who carry a gene mutation that puts them at high risk for Paget's disease of the bone. They previously received either zoledronic acid or a placebo in the ZiPP trial. Now researchers will track them for another 5 years to see if the drug can prevent or d…

This study compares two ways to prevent heart attacks in people at risk: a CT scan of the heart arteries versus the usual risk score method. About 6,139 adults aged 40-70 with risk factors like high blood pressure, diabetes, or smoking are involved. The goal is to see if the CT-g…

This study looks at whether giving blood transfusions to patients who are anemic after leaving the intensive care unit (ICU) can help them feel less tired and recover better. About 346 adults from UK hospitals will be randomly assigned to either the usual care (transfusions only …

This study looks at whether a genetic test can predict who will develop Paget's disease of the bone, a condition that can cause pain, deformity, and hearing loss. Researchers are studying 135 people aged 45 and older who have a parent or sibling with Paget's but do not have the d…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study, called PLINTH, is a feasibility trial for adults who had a stroke from a brain hemorrhage. Researchers want to know if patients and doctors would accept a future platform trial, and how to design it to be inclusive and efficient. About 169 participants will watch an i…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This study follows 440 people with relapsing-remitting multiple sclerosis for 5 to 10 years after their diagnosis. Researchers will use brain scans, lab tests, and genetic information to find patterns that predict how the disease will progress. The goal is to help doctors and pat…

This study surveys general dentists in two UK regions to understand their knowledge and use of silver diamine fluoride (SDF), a liquid that stops tooth decay without drilling or needles. Researchers aim to identify barriers like training gaps or cost that prevent wider use in chi…

This study aims to understand how family doctors in Latin America can provide better palliative care—care that focuses on comfort and quality of life for people with serious illnesses. About 30 to 50 healthcare professionals will share their experiences and ideas through online m…

This study looks at whether a special heart scan (CTCA) can help find hidden heart disease in people who come to the hospital with chest pain but are not having a heart attack. About 3,170 adults with slightly elevated troponin levels (a sign of heart stress) will get the scan to…

The ORACLE study is testing a new way to evaluate people with possible angina (chest pain) within one day of their doctor's referral. Participants fill out a digital health questionnaire at home, then have an ECG and a blood test for heart damage markers. The goal is to see if th…

This study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…

This study compares two ways to train surgeons in laparoscopic (keyhole) surgery: an AI-enhanced game-based simulator (Laptitude) versus a standard box trainer (SurgTrac). About 157 surgical trainees with varying experience will be randomly assigned to one method and then tested …

This study aimed to find out if certain genes that affect bleeding can cause a false positive result on a stool test used to screen for colon cancer. Researchers planned to compare genetic markers in people who had a high test result but a normal colonoscopy with those who had no…

This study follows 124 golfers who have hip, knee, or shoulder replacement surgery. Researchers track how many return to golf, how long it takes, and how their game and joint function change over a year. The goal is to give patients and doctors clear, realistic expectations about…

This study looks at 400 people already in a larger heart disease prevention trial. Researchers will check their diet, exercise, and smoking habits at the start and again after 6 months. The goal is to see if being in the study and learning CT scan results helps people make health…