University Of Edinburgh

This study looks at whether two medications, dapagliflozin and bosentan, can improve blood vessel function in people with large vessel vasculitis (LVV), a condition that raises the risk of heart attacks and strokes. About 60 adults with stable LVV will take both drugs for 6 weeks…

This study tests a new way for people with gout to manage their condition. Participants will either use a smartphone app to check their own urate levels and adjust medication, or receive standard care. The goal is to see if this self-monitoring approach reduces painful gout flare…

This trial is testing several already-approved drugs to see if they can slow down motor neuron disease (MND) and help people live longer. About 1,150 adults with MND will be randomly assigned to receive one of the study drugs or a placebo. The study uses a flexible 'adaptive' des…

This study tests whether a smartphone app can record and analyze speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study tests a new bedside blood test that can diagnose methanol poisoning in minutes using just a drop of blood. Methanol poisoning is hard to spot because its symptoms look like other illnesses, and standard lab tests take hours. The trial will check how accurate and useful…

This study tests a robotic pill camera that can be guided by magnets to examine both the stomach and small bowel in one go. It aims to see if this less invasive method can safely replace standard upper endoscopy for people with iron deficiency anaemia of unknown cause. About 100 …

This study tests a new imaging test (PET-CT scan) that can see blood clots in the heart arteries from outside the body. The goal is to better identify what caused a heart attack, so patients get the right treatment. Researchers will recruit 80 adults who recently had a heart atta…

This study looks at whether a virtual group program can help people with lupus feel less tired. Fatigue is a common and frustrating symptom that often isn't addressed well. The study will compare a 4-week or 7-week online group program plus a booklet to just the booklet alone. 90…

This study looks at whether a special heart scan (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. Heart disease is the leading cause of death after a kidney transplant, and current risk checks aren't good enough. The stud…

This study aims to learn what causes aortic stenosis to get worse and how the heart changes after valve replacement. About 300 adults over age 50 with mild to severe aortic stenosis or a replacement valve will have heart scans every 6 to 12 months. Researchers will use special im…

This study aims to understand why vein grafts used in heart bypass surgery sometimes fail, leading to heart attacks or strokes. Researchers will use advanced total-body PET scans to look at inflammation and clotting inside the grafts. The study will involve 70 adults who recently…

This study will look at 100 adults admitted to NHS mental health wards to learn about their physical and mental health. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like depression, mania, and anxiety. The goal is to bette…

This study tests whether a wrist-worn activity monitor can help doctors understand how people recover after leaving the intensive care unit (ICU). 40 adults who were in the ICU for over a week will wear the device at home and answer health questionnaires. The goal is to see if mo…

This observational study aims to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function to see how these factors relate. The…

This study looks at whether a simple, noninvasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women with and without the condition. The goal is to see if the eyes can provide a new way to monitor the dise…

This study uses advanced total-body PET scans with three different tracers to see if they can accurately measure disease activity in people with ANCA vasculitis, a serious autoimmune condition. Researchers will compare scan results with standard tests and also check heart disease…

This observational study looks at whether leaky blood vessels in the eye can signal similar damage in the brain, which is linked to strokes and dementia. Researchers will inject a fluorescent dye into 40 participants and take detailed eye images. The goal is to see if eye vessel …

This study looks at how to better protect women with experiences like homelessness, substance use, or incarceration from cervical cancer. Researchers will offer HPV testing and vaccination during regular sexual health visits to see if this approach works. About 500 participants i…

This study gathers video and hand-movement data from 300 patients and up to 20 doctors during routine bronchoscopy. The goal is to use this information to create better training tools for new doctors. No extra tests or visits are needed for patients.

This study talks to children with cerebral palsy who have sleep breathing issues, their parents, and healthcare workers. The goal is to learn about their experiences with diagnosis and treatment, like using a breathing mask at night. By gathering these stories, researchers hope t…

This study is testing whether a special type of MRI scan, called manganese-enhanced MRI (MEMRI), can help predict heart and kidney complications in people with kidney disease. Researchers will scan 120 adults with conditions like acute kidney injury, chronic kidney disease, or ki…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will put 104 overweight adults (with and without diabetes) on a very low-calorie diet for 8-12 weeks, then support weight loss for up to a year. …

This study is observing 200 kidney transplant patients in Scotland to see if certain biomarkers (biological signs) can help predict transplant rejection. Researchers will track how many patients experience rejection, confirmed by a biopsy. The goal is to improve long-term outcome…

This study aims to find a better way to detect scarring in the intestines of people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see active scarring, which current tests miss. The goal is to help develop new treatments that prevent permanent bowel …

This study tests whether a new system that uses routine health records and data from a smartphone app can predict asthma attacks in children and young people aged 5 to 17. Researchers will monitor 900 participants, focusing on those at high risk, to see if the system reduces the …

This study aims to collect detailed information from 1000 people in the UK who have endometriosis, a chronic pain condition affecting 1 in 10 women. Participants will use a mobile app to track symptoms, provide biological samples, and wear a smartwatch. The goal is to find better…

This study uses two separate questionnaires to learn about the experiences of people with Takayasu arteritis (TAK) and how doctors manage the condition. Researchers will ask patients about their symptoms, daily life, and treatment priorities, while doctors will share their treatm…

This study aims to better understand broken heart syndrome (takotsubo cardiomyopathy) by using special MRI scans with a dye called manganese. Researchers will also see how different heart medications affect the condition. About 100 adults with this condition will take part.

This study looks at whether a brief conversation in the emergency department can help patients with chest pain understand their future heart attack risk. Researchers will share troponin blood test results and heart health advice with 118 adults who have no prior heart disease but…

This study aims to better understand the role of blood clots in different types of stroke. Researchers will use a special PET scan tracer that sticks to activated platelets, the cells that form clots, to see where clots are in the body. The study will involve 120 adults who have …

This study is testing whether wearable sensors (like a chest patch and finger clip) can detect early signs that a patient is getting worse after surgery. Over 1,300 adults having major surgery in 8 countries will wear the sensors for up to 10 days. The data will be used to design…

This study collects and freezes testicular tissue from prepubertal boys who are about to receive cancer treatment that is very likely to cause infertility. The tissue is stored for possible future use to restore fertility, and a portion is used for research to understand how sper…

This study is for people with stomach, pancreas, or bowel cancer who are having surgery, as well as some people without cancer for comparison. The goal is to understand why some patients lose muscle and weight (cachexia) and how it affects their recovery. Researchers will track c…

This study aims to understand how inflammation, tiny calcium deposits, and blood clots behave in the leg arteries of people with peripheral artery disease (PAD). About 100 adults with PAD will receive three different PET scans to measure these activities. The results will help re…

This study looks at how scarring (fibrosis) develops in the heart muscle due to conditions like aortic stenosis, chemotherapy side effects, and carcinoid syndrome. Researchers will use special PET scans to detect this scarring early and see if it is actively forming. About 180 ad…

This study looks at how common sleep breathing problems are in children with cerebral palsy (CP) and how many use breathing machines at night. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to improve early detection and…

This study is testing a new blood test that looks for tiny pieces of cancer DNA in the bloodstream of people with throat cancer. The goal is to see if this test can accurately track how well treatment is working and spot cancer returning earlier than current methods. Researchers …

This study looks at whether a simple, point-of-care test can check pregnancy hormone levels just 2-4 days after an early abortion (under 6 weeks) instead of waiting the usual 7 days. Researchers will enroll 130 people and compare the early test results with the standard 7-day tes…

This study looks at how blood pressure and artery stiffness change between day and night in people at higher risk for heart disease, including those with kidney problems. Researchers will monitor 120 participants over 24 hours using wearable devices and collect blood and urine sa…