University Of Edinburgh

This study compares two ways of managing gout: a supported self-management approach where patients monitor their own urate levels with a finger-prick test and adjust medication via a smartphone app, versus usual care where a doctor manages treatment. The goal is to see if the sel…

This study tests several already-approved drugs to see if they can slow down motor neuron disease (MND) and help people live longer. About 1150 adults with MND will be randomly assigned to receive one of the study drugs or a placebo. The trial uses a flexible design, allowing ine…

This study tests whether two drugs—bosentan and dapagliflozin—can improve blood vessel function in people with large vessel vasculitis, a condition that damages arteries and raises the risk of heart attacks and strokes. Sixty adults with stable disease will take both drugs for 6 …

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study tests a robot-assisted capsule (a pill-sized camera) to examine the stomach and small bowel in people with iron deficiency anaemia whose cause hasn't been found by standard tests. The goal is to see if this less invasive method works as well as traditional upper endosc…

This study tests a new bedside test that uses a single drop of blood to diagnose methanol poisoning, a major problem in low-income countries. The test measures formate, a toxic byproduct of methanol, and could give results in minutes instead of hours. The trial will first check h…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study is testing a smartphone app that records and analyzes speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

This study aims to make cervical cancer prevention easier for women who often miss out on routine care, such as those experiencing homelessness, substance use, or incarceration. Researchers will offer the HPV vaccine (Gardasil-9) and a self-swab test during regular sexual health …

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether online group programs to manage fatigue can help people with lupus. Participants will either receive a fatigue booklet alone or also attend online group sessions (4 or 7 weeks long). The goal is to see if the programs reduce fatigue impact and improve qua…

This study looks at how repeated short-term cold exposure affects brown adipose tissue (brown fat), a type of body fat that burns energy to generate heat. Twelve healthy adults will undergo a 10-day cold acclimation protocol using cooling blankets. Researchers will take tissue sa…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study tests a new PET scan technique to better track heart damage in people with a condition called ATTR-CM, a progressive heart muscle disease. Researchers will scan 140 participants to see if the imaging can show how well treatments are working. The goal is to improve moni…

ENDO1000 is a UK-wide research project involving 1000 people with endometriosis. Participants will use a mobile app to track symptoms like pain, fatigue, and sleep, and some will provide blood, urine, and other samples at home. The goal is to collect detailed data over time to he…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This study looks at why immune cells in people with COPD don't work properly to clear bacteria from the lungs. Researchers will collect cells from the lungs and blood of 189 participants, including COPD patients and healthy smokers and non-smokers. They will study how these cells…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This study looks at whether giving patients who come to the emergency department with chest pain a simple explanation of their heart disease risk can help them understand and improve their health. Researchers will talk with 118 adults in Scotland who have slightly elevated tropon…

This study is testing whether a simple, rapid blood test can confirm that a very early medical abortion (under 6 weeks) has worked. Usually, women need to wait 7 days for a follow-up blood test. This study checks if the test can be done as early as 2-4 days after treatment. Resea…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

This study tests whether a wrist-worn activity monitor can help doctors understand how people recover after leaving the intensive care unit (ICU). 40 adults who spent more than a week in the ICU will wear the device for two months at home and answer health questionnaires. The goa…

This study uses advanced total-body PET scans to look inside vein grafts after coronary artery bypass surgery. Researchers want to understand why some grafts fail, leading to heart attacks or strokes. They will scan 70 patients—some soon after surgery and others years later—to tr…

This study aims to better understand takotsubo cardiomyopathy, also known as broken heart syndrome, by using manganese-enhanced MRI scans. Researchers will test how different heart medications affect manganese uptake in the heart muscle. The study involves 100 adults who have had…

This study is testing a blood test that looks for tiny pieces of cancer DNA in the bloodstream of people with throat cancer. The goal is to see if this test can track how well treatment is working and spot if the cancer comes back earlier than current methods. Researchers will co…

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study uses a special eye dye test to see if leaky blood vessels in the eye are linked to leaky blood vessels in the brain. Researchers will compare eye images with brain scans from 40 people who have had a mild stroke or related brain disease. The goal is to learn more about…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This study is testing whether a special full-body PET scan can more accurately detect active ANCA-associated vasculitis (AAV) and predict long-term heart disease risk. Researchers will scan up to 120 participants (some with active AAV, some healthy) using three different tracers …

This study is testing whether a special CT scan of the heart (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. About 332 patients on the transplant list will get a single CTCA scan before their surgery. Researchers will th…

This study is testing whether wearable sensors on the chest and fingers can detect early signs of patient decline after major surgery. Over 1,300 adults in eight countries will wear the sensors before, during, and after their operation for up to 10 days. The data will be used to …

This study is tracking 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will compare biomarker levels with standard biopsy results. The goal is to find a simpler, less invasive way to monitor transplant hea…

This study uses two online questionnaires to learn about the experiences of people with Takayasu arteritis and how doctors manage the condition. About 50 patients and an unspecified number of physicians in the UK will share their views on symptoms, treatment priorities, and unmet…

This study will enroll 900 children aged 5-17 with asthma to see if remote monitoring—using routine health data and a smartphone app—can predict asthma attacks. Researchers will track whether this system reduces the number of attacks compared to past averages. A subset of high-ri…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

This study follows 200 people with cancers of the esophagus, stomach, pancreas, colon, or rectum who are scheduled for surgery, along with some healthy controls. Researchers will track weight, muscle mass, physical activity, quality of life, and immune markers over a year to bett…

This study looks at whether a simple, non-invasive eye scan can detect signs of inflammation in women with endometriosis. Researchers will compare retinal images from 100 women—half with endometriosis and half without—to see if the eyes can reveal information about this condition…

This study collects and freezes testicular tissue from prepubertal boys before they start cancer treatment that has a high risk of causing infertility. The tissue is stored for potential future use to restore fertility and for research to better understand germ cell development. …

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…

This study tests a new imaging method using a special dye (FAPI) to detect bowel scarring in people with Crohn's disease. Scarring affects up to half of patients and often leads to surgery, but current tests can't spot it early. The study will involve 30 adults starting biologic …

This observational study in Scotland aims to understand what causes aortic stenosis to worsen and how the heart responds after valve replacement. About 300 participants with mild to severe aortic stenosis or a replacement valve will undergo regular heart scans and imaging over se…

This study gathers video and hand-movement data from 300 patients and up to 20 doctors during routine bronchoscopy procedures. Researchers aim to use this data to create machine learning models that could help train new doctors. No new treatments or drugs are involved, and patien…