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Scientists use advanced scans to peek inside artery plaques

NCT ID NCT07472049

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 18, 2026 · Updated 2 times

Summary

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the body. The study involves 100 adults with symptomatic PAD and does not test any new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients will be prosectively recruited from vascular outpatient clinics and inpatient wards.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female aged \> 18 years * Symptomatic atherosclerotic peripheral artery disease; * Intermittent claudication; with ankle/arm blood pressure ratio \<0.90 or artery stenosis \>50% in addition to at least one of the following; * \>1 vascular bed affected by atherosclerosis * Diabetes * Heart failure * Chronic kidney disease (eGFR \< 60 mL/min/1.73 m2) * Rest pain or necrosis of limb or gangrene of limb * Revascularization defined as limb bypass surgery or endovascular revascularization procedures (irrespective of the specific device used), including percutaneous transluminal angioplasty/stent of iliac or infra-inguinal arteries or extra-anatomical bypass surgery * Leg or foot amputation for arterial vascular indications * Ability to give written or verbal informed consent Exclusion Criteria: * Contraindication to colchicine or iodinated contrast * Long term requirement for colchicine for another clinical indication * Active diarrhoea * Recent lower limb revascularisation for symptomatic disease (\<6 weeks) * Renal failure (glomerular filtration rate \<30 mL/min/1.73 m2) * Cirrhosis or severe chronic liver disease * Women who are pregnant or breast-feeding * Women of child-bearing potential not protected by reliable contraception or is planning conception during the study * Current or planned long term use of cyclosporine, verapamil, HIV protease inhibitors, azole antifungals, or macrolide antibiotics (apart from azithromycin) * Patients deemed unlikely to return for follow up * Life expectancy \<1 year * Inability or unwilling to give informed consent

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Chronic Limb-Threatening Ischemia limb ischemia peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic limb-threatening ischemia Peripheral arterial disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, Midlothian, EH16 4SA, United Kingdom

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