PERIPHERAL ARTERIAL DISEASE

This study aims to find the best length of time for patients to take two blood thinners after having a procedure to open blocked leg arteries. Researchers want to see if taking the medications for six months instead of one month keeps arteries open better without causing more ble…

This study is testing whether using ultrasound imaging inside blood vessels during leg artery procedures helps patients with poor leg circulation. Researchers want to see if this imaging technique leads to better blood flow, fewer repeat procedures, and improved quality of life. …

This study is testing a new procedure for patients with severe leg artery disease who have no other treatment options left and face amputation. Doctors will try to save the limb by surgically redirecting blood flow from an artery into the deep veins of the foot. The goal is to se…

This study is testing a new, gentle leg movement therapy for people with peripheral artery disease (PAD), a condition that reduces blood flow to the legs. Researchers want to see if moving the legs passively (without muscle effort) during long periods of sitting can improve blood…

This study is testing whether performing a procedure to open blocked leg arteries within 48 hours helps diabetic foot ulcers heal better than waiting for a standard scheduled procedure. It will involve 200 adults with type 2 diabetes and a foot ulcer. Researchers will use a 3D ca…

This study is testing a new type of balloon coated with a drug (SELUTION SLR™ 014) to see if it works better than a standard balloon at keeping leg arteries open. It is for patients with severe blockages in the arteries below the knee who are at risk of amputation. The goal is to…

This early-stage study is testing if a single dose of an existing drug, diroximel fumarate (Vumerity), can help people with peripheral artery disease (PAD) walk better. Researchers believe the drug may reduce harmful stress in blood vessels, improving blood flow to the legs. Abou…

This study compares two different guidance methods for accessing blocked leg arteries during minimally invasive procedures. Researchers want to see which approach—using road mapping or ultrasound—is more successful and causes fewer complications. The study includes 32 adults with…

This study is collecting long-term data on two specific types of artificial blood vessels (grafts) used in surgery to repair or replace blocked arteries in the legs. It aims to see how safe and effective these grafts are over several years by tracking whether they stay open and i…

This study is tracking the safety and performance of a specific drug-coated stent (ZENFLEX Pro™) after it has been approved for use. The stent is used to open blocked arteries in the thigh and knee area to improve blood flow to the legs. Researchers will follow 153 patients for o…

This study is testing a new medical device called the EVSS, which is a small scaffold or stent, to open blocked arteries in the leg. It aims to see if the device is safe and can improve blood flow for people with leg pain or cramping caused by peripheral artery disease. The study…

This study is collecting real-world data on a specific drug-coated balloon used to treat blocked leg arteries (peripheral arterial disease). It will follow about 284 patients in Europe for three years after their procedure to see how safe the treatment is and how well it works at…

This large, late-stage trial is testing whether a low daily dose of an existing anti-inflammatory drug (colchicine) can prevent serious complications in people with symptomatic peripheral artery disease (PAD). It aims to see if the drug reduces the combined risk of heart attacks,…

This small study in Malaysia is observing whether injections of a stem cell product (Stempeucel®) can help patients with severe blockages in their leg arteries. The goal is to see if the treatment reduces pain, helps ulcers heal, improves walking distance, and prevents amputation…

This study is testing whether a special heat therapy device can improve blood flow in the lower legs and feet of veterans. Ten veterans with both poor leg circulation (peripheral artery disease) and nerve damage (neuropathy) will use the device twice daily for three months. Resea…

This study is collecting information on patients who have already had a procedure using the Pounce Thrombectomy System. The device is designed to remove dangerous blood clots from leg arteries without major surgery. Researchers will look at how well the procedure worked and track…

This study is testing a device that uses sound waves (shockwaves) to break up hard calcium deposits in the main artery of the thigh. It aims to see if this procedure improves pain, walking ability, and blood flow for 50 people with severe peripheral artery disease. Researchers wi…

This study is testing whether a once-daily pill called orforglipron can help people with peripheral artery disease (PAD) walk farther with less leg pain. About 1,200 participants with PAD will take either the study drug or a placebo pill for about a year. The main goal is to see …

This study is testing the safety and effectiveness of the Golazo device, a tool that shaves away plaque to open blocked arteries in the legs. It will involve 159 people with symptomatic peripheral arterial disease (PAD) at up to 20 U.S. sites. The main goal is to see if the proce…

This small pilot study is testing whether a special type of compression stocking, called a 'Fuzzy Wale' stockinet, can help people heal better after a below-the-knee amputation due to poor leg circulation. Researchers will compare it to the standard compression stocking to see if…

This study is testing if a device that sends electrical pulses to the spinal cord can help reduce leg pain in people who have both painful diabetic nerve damage and poor blood circulation. Up to 15 participants who already have the device implanted will try two weeks of real stim…

This study is testing whether a dietary supplement called MitoQ, taken daily for six months, can help people with peripheral artery disease (PAD) who get leg pain when walking. Researchers want to see if MitoQ helps participants walk farther, be more active, feel better, and impr…

This study is comparing a newer surgical technique called Ewing Amputation to the standard method for Veterans needing a below-knee amputation due to poor circulation. The goal is to see if the newer technique helps Veterans walk better, improves their balance, and reduces pain a…

This large observational study is collecting real-world data to compare how well two common treatments—using stents versus not using stents—work for people with peripheral artery disease (PAD) in their legs. It will follow 14,000 patients who have already had one of these procedu…

This study aims to understand the relationship between the bacteria in a person's mouth, how well blood flows to their muscles, and their overall fitness level. Researchers want to see if these factors are connected, especially in people with heart conditions or who are overweigh…

This study aims to better understand the processes that cause artery blockages in people with leg pain from poor circulation. Researchers will perform full-body scans on 100 participants to see how inflammation and calcification in leg arteries relate to plaque in other arteries,…