PERIPHERAL ARTERIAL DISEASE

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can reduce the risk of serious heart problems and limb complications in people with peripheral artery disease (PAD). About 6,150 adults with symptomatic PAD will take either colchicine or a placebo dail…

This study looks at people with peripheral artery disease who have had a procedure to open blocked leg arteries. It compares taking two blood thinners for 1 month versus 6 months after the procedure. The goal is to see which approach keeps arteries open longer without causing mor…

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries (peripheral artery disease). The scaffold is placed inside the artery to hold it open and improve blood flow. The goal is to see if it is safe and works well …

This study tests a special catheter that uses sound waves (shockwaves) to break up calcium buildup in the leg arteries. This makes it easier for doctors to place a large stent in the aorta to treat aortic disease. The study will include 40 adults with severely calcified arteries …

This study tests whether a new type of stent (GORE VBX) works better than standard metal stents for people with blocked arteries in the pelvis (iliac arteries). About 244 adults with leg pain or tissue loss due to poor blood flow will be randomly assigned to receive either the ne…

This study looks back at medical records of up to 500 people who had a procedure using the Pounce Thrombectomy System to remove blood clots from arteries in the legs. The goal is to see how well the device restores blood flow and how safe it is. Participants are adults who alread…

This study tests a new drug called SRSD107, given as a shot under the skin, in people with long-term coronary or peripheral artery disease. The goal is to see if it can safely reduce a clotting factor in the blood, potentially lowering the risk of heart attacks or strokes. About …

This study tests whether fisetin, a natural compound, can reduce aging cells in the body and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will take fisetin or a placebo for 4 months. The main goal is to see if fisetin helps them…

This study tests a new procedure that reroutes blood flow in the foot to save the leg from amputation. It is for people with severe leg artery disease who have no other treatment options. The study will check if the procedure is safe and works well in 50 participants.

This study tests the Golazo® device, which removes plaque from leg arteries in people with peripheral arterial disease (PAD). About 159 adults with moderate to severe symptoms will be treated at up to 20 U.S. sites. The goal is to see if the device is safe and effective at restor…

This study is testing a new device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to s…

This study tests a new balloon catheter coated with everolimus to open blocked arteries in the leg. About 410 people with peripheral artery disease will be randomly assigned to get either the new balloon or a standard paclitaxel-coated balloon. The goal is to see if the new ballo…

This study tests a new procedure that reroutes blood flow through a leg vein to save the limb in people with severe, late-stage blocked leg arteries (chronic limb-threatening ischemia). About 100 participants with non-healing wounds or gangrene will receive the LimFlow device. Th…

This study is testing a special balloon coated with a drug (paclitaxel) to open blocked arteries in the legs. About 284 people with peripheral artery disease will receive this treatment during a standard procedure. The goal is to see if the balloon keeps arteries open longer and …

This study looks at whether opening blocked leg arteries within 48 hours helps heal foot ulcers in people with type 2 diabetes. About 200 adults with diabetic foot ulcers will be randomly assigned to early or standard treatment. Researchers will track wound healing with a 3D came…

This study is testing a special drug-coated stent called ZENFLEX Pro™ to treat blocked or narrowed arteries in the leg (a condition called peripheral artery disease). The goal is to see if the stent keeps the artery open for at least 12 months. About 153 people with leg pain or s…

This study is a registry that will follow 1000 people who have had surgery to repair or replace a blocked artery in their leg using either the Advanta VXT or Flixene graft. The goal is to see how well these grafts work and how safe they are over the long term, by checking for com…

This study tests a special balloon coated with medication (SELUTION SLR™ 014) to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 participants will be randomly assigned to receive either the drug-coated balloon or a s…

This study tests whether using a tiny ultrasound camera inside the blood vessels during a minimally invasive leg artery procedure leads to better results for people with peripheral artery disease. About 350 adults with leg pain or wounds due to blocked arteries will be enrolled. …

This study tests whether adding nitrate-rich beetroot juice to exercise (either supervised treadmill sessions or home walking) improves walking distance more than exercise alone in people with peripheral artery disease (PAD). About 210 adults aged 50 and older with PAD will be ra…

This study tests a stem cell product called Stempeucel in 10 Malaysian adults with critical limb ischemia, a severe form of peripheral artery disease that causes leg pain and ulcers. The treatment is given as an injection into the leg muscles. Researchers want to see if it can re…

This study aims to develop a new, noninvasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and monitor how the disease changes over time or after treatment. Researchers at Mayo Clinic will enroll 400 adults, including those with PAD symptoms and health…

This study compares a new type of below-knee amputation (called Ewing amputation) to the standard surgery in veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. About 120 veterans will be randomly assigned to one of t…

This study looks at whether doing handgrip exercises for 12 weeks can lower blood pressure in people with peripheral artery disease (PAD). Researchers will split 30 participants into two groups: one does handgrip training, the other is encouraged to be more active. Blood pressure…

This study tests whether a single dose of the drug Vumerity can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). Researchers will give 20 adults aged 50-75 either Vumerity or a placebo and measure changes in blood flow, oxygen use,…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce severe leg pain and improve blood flow in people with both painful diabetic neuropathy and peripheral artery disease. Fifteen adults who already have a permanent s…

This study tests whether a fuzzy compression sock can help wounds heal faster after a leg amputation due to poor blood flow. About 40 adults will either get the special sock or standard care. Researchers will track infections, pain, and how soon a prosthetic leg can be fitted.

This study is testing whether a device called Replexa+, which uses shortwave diathermy, can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will use the device twice daily for three months.…

This study tests a once-daily pill called orforglipron in 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if it safely improves how far they can walk and their quality of life over about 58 weeks. Participants will take the pill…

This study tests a type of exercise called Blood Flow Restriction (BFR) training in 81 adults with peripheral arterial disease (PAD), a condition that causes leg pain when walking. The goal is to see if BFR training can improve walking distance, quality of life, and safety compar…

This study tests whether taking MitoQ for six months can improve walking ability and reduce leg pain in people with peripheral artery disease (PAD). Researchers will measure walking distance on a treadmill and during a 6-minute walk, as well as daily activity and quality of life.…

This study looks at how your fitness level relates to the bacteria in your mouth and how well blood flows to your muscles. Researchers will collect mouth swabs, saliva, and have participants do a cycling test. The goal is to understand these connections in people with heart failu…

This study compares two techniques for guiding a needle into a blocked leg artery during angioplasty: road mapping (using X-ray images) versus ultrasound (using sound waves). The goal is to see which method is more successful and causes fewer complications like bruising or artery…

This study looks at whether a device that gently moves the legs back and forth (like paddling) can improve blood flow and walking ability in people with peripheral artery disease (PAD) during long periods of sitting. About 24 adults aged 50-85 with PAD and healthy controls will e…

This study looks at whether a simple leg strength test (the 30-second sit-to-stand test) done over a video call gives the same results as when done in person. Researchers will enroll 45 adults with peripheral artery disease to compare the two methods. If reliable, tele-assessment…

This study is collecting information from 14,000 people with peripheral artery disease (PAD) to compare outcomes between those who received a stent and those who received other treatments without a stent. Researchers will track events like repeat procedures, amputations, and walk…

This study aims to understand how inflammation, tiny calcium deposits, and blood clots behave in the leg arteries of people with peripheral artery disease (PAD). About 100 adults with PAD will receive three different PET scans to measure these activities. The results will help re…