PERIPHERAL ARTERIAL DISEASE

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study compares a new balloon coated with everolimus to standard paclitaxel-coated balloons for opening blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to one of the two balloons. The goal is to see if the new ba…

This study tests a new tool called Golazo that removes plaque from leg arteries in people with peripheral artery disease (PAD). About 159 adults with moderate to severe symptoms will be treated at up to 20 U.S. sites. The goal is to see if the device is safe and works well to imp…

This study tests whether a fabric-covered stent (GORE VBX) works better than standard bare metal stents for people with severe blockages in the iliac arteries, which supply blood to the legs. About 244 participants with leg pain or tissue loss will be randomly assigned to receive…

This study tests a device that uses light and magnets (COMS) to help heal chronic leg ulcers. About 122 people with venous leg ulcers will receive either standard care plus COMS or standard care alone. The goal is to see if the device speeds up wound healing and improves quality …

This study tests whether using a special shockwave device to break up calcium before placing a stent works better than the usual balloon angioplasty in people with peripheral artery disease (PAD) and heavily calcified leg arteries. About 120 participants will be randomly assigned…

This study looks at whether doing handgrip exercises for 12 weeks can lower blood pressure in people with peripheral artery disease (PAD). Researchers will split 30 participants into two groups: one does handgrip training, the other is encouraged to be more active. Blood pressure…

This study tests a special balloon coated with medicine (SELUTION SLR™ 014) to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 adults with chronic limb-threatening ischemia will be randomly assigned to get either the…

This study tests an investigational drug called SRSD107 in people with chronic coronary artery disease or peripheral arterial disease. The goal is to see if it safely reduces a protein involved in blood clotting, which may lower the risk of dangerous clots. About 104 adults will …

This study is testing a device called the LimFlow Stent Graft System for people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease where blood flow to the leg is critically low. The device creates a new connection between a vein and arte…

This study compares taking two blood thinners (clopidogrel and aspirin) for 1 month versus 6 months after a leg artery procedure. The goal is to see if the longer treatment keeps the treated artery open longer and prevents serious events like heart attack or stroke without causin…

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major a…

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries that cause pain or trouble walking. The scaffold is placed inside the artery to hold it open and improve blood flow. Researchers will check if the device is s…

This study tests whether a daily low dose of colchicine, an anti-inflammatory drug, can prevent heart attacks, strokes, and severe leg complications in people with peripheral artery disease (PAD). About 6,150 participants with symptomatic PAD will receive either colchicine or a p…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study tests whether using carbon dioxide gas instead of standard iodinated contrast dye during leg artery procedures can prevent serious kidney problems. About 1,960 people with peripheral artery disease who are at higher risk for kidney injury will be randomly assigned to r…

This study tests whether using a tiny ultrasound camera inside the blood vessels during a minimally invasive leg artery procedure leads to better results for people with peripheral artery disease. About 350 adults with leg pain or wounds from blocked arteries will be randomly ass…

This registry follows 1000 people who received Advanta VXT or Flixene grafts to repair peripheral arteries. Researchers will check how well the grafts stay open and how often serious problems like amputation or repeat surgery occur. The goal is to confirm these devices are safe a…

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study tests whether a gel made from a patient's own blood, called Plasma Rich in Growth Factors (PRGF), can heal foot ulcers better than standard care. It includes 38 diabetic adults with poor leg blood flow. The treatment is applied topically during regular wound care visit…

This study is checking how safe and effective the ZENFLEX Pro drug-eluting stent is for people with peripheral artery disease (PAD) — narrowed or blocked arteries in the leg. About 153 adults with leg pain or sores will get the stent and be followed for a year. The main goal is t…

This study is tracking 500 people who had a procedure using the Pounce Thrombectomy System, a device that removes blood clots from arteries in the legs without open surgery. The goal is to see how well the device restores blood flow and how safe it is. The study is retrospective,…

This study tests whether injecting donor stem cells (Stempeucel) into the leg muscle can help people with critical limb ischemia, a severe form of peripheral artery disease. Ten Malaysian patients who cannot have surgery or angioplasty will receive the stem cells and be followed …

This study at Mayo Clinic is testing a new, non-invasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and more easily. Researchers will compare the ultrasound results with standard tests like ankle-brachial index and CT scans. The study includes 400 pe…

This study tests whether a personalized exercise program—focusing on the specific leg muscles affected by blocked arteries—can help people with peripheral arterial disease walk longer distances without pain. Participants are randomly assigned to either a tailored muscle-strengthe…

This study tests a once-daily pill called orforglipron in about 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed f…

This early-phase trial tests whether a single dose of Vumerity (diroximel fumarate) can improve blood vessel function and walking ability in 20 people aged 50-75 with peripheral artery disease (PAD). Participants will receive either Vumerity or a placebo, and researchers will mea…

This study tests whether a special exercise program using blood flow restriction cuffs can improve walking ability and quality of life in people with peripheral arterial disease (PAD). About 81 adults with stable leg pain from PAD will do low-intensity calf raises while wearing c…

This pilot study tests whether fisetin, a natural compound found in strawberries, can reduce aging cells and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will receive either fisetin or a placebo for 4 months. The main goal is to…

This study tests whether adding nitrate-rich beetroot juice to exercise helps people with peripheral artery disease (PAD) walk farther and with less pain. 210 adults aged 50+ with PAD will be assigned to either supervised treadmill or home walking, plus either beetroot juice or a…

This study tests whether taking MitoQ for six months can improve walking ability and quality of life in people with peripheral artery disease who experience leg pain while walking. Researchers will measure treadmill walking distance, daily step counts, and leg muscle health in 60…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests whether a fuzzy wale compression stockinet can help wounds heal faster and lower costs after a leg amputation due to poor blood flow. About 40 adults will be enrolled. The goal is to see if this special sock reduces infections, pain, and time until a prosthetic l…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study looks at whether a simple leg strength test, the 30-second sit-to-stand test, gives the same results when done over a video call as in person. Researchers will enroll 45 adults with peripheral artery disease (PAD) to compare both methods. If remote testing proves relia…

This study uses MRI scans to look at plaque buildup in leg arteries of people with peripheral arterial disease. Researchers want to see which plaques are hard to cross with a guidewire and which devices cause the least damage to the vessel wall. The study includes patients underg…

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study compares two techniques for guiding a needle into a blocked leg artery from the opposite direction (retrograde). One uses a live X-ray map, the other uses ultrasound. Researchers want to see which is safer and more successful in 32 people with severe leg artery disease…

This study is creating a large registry of 14,000 people with peripheral artery disease (PAD) to compare the long-term results of treatments that use stents versus those that do not. Researchers will track outcomes like repeat procedures, amputations, and walking ability over 12 …

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study tests a simple, passive leg movement called LEAP therapy in people with peripheral artery disease (PAD). Participants sit for 2.5 hours with or without the leg movement, and researchers measure blood flow, walking ability, and other health markers. The goal is to see i…

This study is testing whether a new imaging device called MIMOSA Pro can measure oxygen levels in leg tissue as accurately as standard tests like ankle-brachial index or Doppler ultrasound. Researchers will compare the device's readings to those from traditional methods in 60 adu…