Desperate measure: rerouting veins to save legs from amputation

NCT ID NCT06277362

Recruiting now Disease control Sponsor: EndoCore Lab s.r.l. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major amputation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: percutaneous deep foot venous arterialization procedure
What this could lead to: If it works, this could provide a way to save limbs and avoid amputation in patients with severe leg artery disease who cannot have standard treatments.
What could go wrong: This is an early study with only 50 participants, so results may not apply to everyone. The procedure carries risks like bleeding, infection, or failure to restore blood flow.

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Conditions

The condition(s) this trial relates to.

Diabetic Foot limb ischemia peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL LIMB-THREATENING ISCHEMIA DIABETIC FOOT PERIPHERAL ARTERIAL DISEASE

Contacts and locations

Locations

Arcispedale Santa Maria Nuova
WITHDRAWN

Reggio Emilia, Italy, 42122, Italy
Azienda Ospedaliera S. Maria della Misericordia
NOT_YET_RECRUITING

Perugia, Perugia, 06156, Italy
Irccs Inrca
RECRUITING

Ancona, Ancona, 60129, Italy
Ospedale Bufalini
RECRUITING

Cesena, Italy, 47521, Italy
Ospedale Cardarelli
RECRUITING

Naples, Italy, 80131, Italy
Ospedale Pederzoli
RECRUITING

Peschiera del Garda, Veneto, 37019, Italy
Ospedale San Martino
RECRUITING

Belluno, Italy, 32100, Italy
Ospedale Santa Chiara
RECRUITING

Trento, Italy, 38123, Italy
Ospedale di Conegliano - USLL2
WITHDRAWN

Conegliano, Italy, 31015, Italy

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