Beetroot juice may boost heart blood flow and walking in leg artery disease
NCT ID NCT02553733
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during exercise due to reduced blood flow. Participants will consume either beetroot juice or a placebo that looks and tastes the same but has the nitrate removed. The study measures how long they can walk on a treadmill and changes in coronary blood flow during leg exercise.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- beetroot juice (dietary nitrate)
- What this could lead to
- If effective, beetroot juice could become a simple dietary supplement to help people with peripheral arterial disease walk farther with less leg pain.
- What could go wrong
- This is a small early-stage trial, so results may not apply widely. Beetroot juice can cause harmless red urine or stool, and people on certain heart medications should avoid it.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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