Beetroot juice may boost heart blood flow and walking in leg artery disease

NCT ID NCT02553733

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during exercise due to reduced blood flow. Participants will consume either beetroot juice or a placebo that looks and tastes the same but has the nitrate removed. The study measures how long they can walk on a treadmill and changes in coronary blood flow during leg exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
beetroot juice (dietary nitrate)
What this could lead to
If effective, beetroot juice could become a simple dietary supplement to help people with peripheral arterial disease walk farther with less leg pain.
What could go wrong
This is a small early-stage trial, so results may not apply widely. Beetroot juice can cause harmless red urine or stool, and people on certain heart medications should avoid it.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

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