Limb ischemia

This pilot study tests whether giving special nutritional shakes before and after surgery can improve the health of patients with critical limb ischemia, a severe form of peripheral artery disease. About 30 participants will drink the shakes for one to two weeks before and after …

This study tests whether taking two blood thinners (aspirin and clopidogrel) for 12 months after leg artery surgery is better than taking them for just 1 month in people with severe leg artery disease. The goal is to see if longer treatment prevents amputations or death. About 61…

This study compares a paclitaxel-coated balloon to a standard balloon for opening blocked arteries below the knee in people with chronic limb-threatening ischemia, a serious condition that can lead to amputation. About 288 participants will be randomly assigned to one of the two …

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study is testing a device called the Indigo Aspiration System to remove blood clots from leg arteries in people with acute limb ischemia, a condition where a clot suddenly blocks blood flow. About 300 participants will undergo a procedure where the device sucks out the clot.…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study is testing a device that uses sound waves to break up calcium buildup in leg arteries of people with chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease. Researchers will track 400 patients to see if the treatment helps wounds heal and …

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests a special balloon coated with medicine (SELUTION SLR™ 014) to open blocked arteries below the knee in people with severe leg pain or wounds that threaten the limb. About 376 adults with chronic limb-threatening ischemia will be randomly assigned to get either the…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study is testing a device called the LimFlow Stent Graft System for people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease where blood flow to the leg is critically low. The device creates a new connection between a vein and arte…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests a new drug called APAC, which is designed to prevent blood clots in people with blocked leg arteries. The trial includes 42 adults with peripheral arterial disease or chronic limb-threatening ischemia. Researchers will check if APAC is safe and well-tolerated, an…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major a…

This study is tracking 1,000 people with severe leg artery disease (chronic limb-threatening ischemia) who are getting a drug-coated balloon to open blocked arteries below the knee. The balloon releases a drug (paclitaxel) to help keep the artery open. Researchers want to see if …

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This early-stage study tests a new tube (cannula) placed in the leg artery during heart surgery that uses a heart-lung machine. The device is designed to keep blood flowing to the leg, reducing the risk of limb damage. Fifteen adults having planned heart surgery will be enrolled,…

This study tests a new type of stent that slowly dissolves and releases medication to keep leg arteries open. It is for people with chronic limb-threatening ischemia, a serious condition where blocked arteries can lead to amputation. About 300 participants will be randomly assign…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study tests whether a laser device called the Auryon Atherectomy System, used with standard balloon angioplasty, works better than balloon angioplasty alone for people with severe leg artery blockages (critical limb ischemia). The trial will enroll 224 adults who are at risk…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study compares two methods for opening blocked arteries in the lower leg in people with chronic limb-threatening ischemia, a severe condition that can lead to amputation. One group gets standard balloon angioplasty guided by X-ray images (angiography). The other group uses a…

This study tests a drug called Fortelyzin, which is injected directly into blood clots to dissolve them, in people with acute limb ischemia (sudden loss of blood flow to a limb). The goal is to see if it can prevent amputation as well as or better than standard surgery. About 170…

This study is testing a device that uses sound waves to break up calcium buildup in the leg arteries of people with peripheral artery disease. The goal is to improve blood flow, reduce pain, and help people walk better. About 50 participants will be followed for one year to see i…

This study is tracking 500 people who had a procedure using the Pounce Thrombectomy System, a device that removes blood clots from arteries in the legs without open surgery. The goal is to see how well the device restores blood flow and how safe it is. The study is retrospective,…

This study tests whether injecting donor stem cells (Stempeucel) into the leg muscle can help people with critical limb ischemia, a severe form of peripheral artery disease. Ten Malaysian patients who cannot have surgery or angioplasty will receive the stem cells and be followed …

This study is testing whether injections of Stempeucel, a stem cell product made from donor bone marrow, can help people with critical limb ischemia caused by Buerger's disease. The goal is to see if it reduces pain, heals ulcers, improves blood flow, and prevents amputation. Onl…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study tests whether music therapy delivered by the BeatMove device can help people with leg artery disease walk farther during a 3-month outpatient walking program. Fifty-four participants will either get real music therapy or a sham version while doing 36 walking sessions. …

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study explores whether a thermal imaging camera can detect changes in blood flow to the legs after a procedure to reopen blocked arteries. Researchers will compare temperature readings from the camera with standard ankle-brachial index measurements in 25 people with severe p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study tests a new device called the Spur scaffold, used with a drug-coated balloon, to treat blocked arteries below the knee in people with chronic limb-threatening ischemia (CLTI). The study includes 40 high-risk patients—those with diabetes or on dialysis—and measures how …

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study is testing whether a quick ultrasound measurement of blood flow in the foot (called systolic rise time) can predict major limb events like amputation or severe ischemia in people with critical limb ischemia. Researchers will follow 134 patients for 6 months after surge…

This study looks at whether giving extra oxygen through a mask (normobaric oxygen therapy) can help people with critical limb ischemia, a severe lack of blood flow to the legs that can lead to amputation. Researchers will compare the health and treatments of 200 patients who do o…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study tests whether a new type of PET/MR scan using a tracer called FAZA can measure oxygen levels in leg tissues of people with critical limb ischemia, a severe form of peripheral artery disease. About 40 adults who are scheduled for a procedure to restore blood flow will g…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study tests whether non-invasive sensors can detect reduced blood flow in the legs during long pelvic surgeries. Thirty adults will be monitored during their procedure. The goal is to see if this approach can help prevent complications like limb ischemia.

This study looks at immune cells called macrophages in the arteries of people with heart disease or poor leg circulation. Researchers will use imaging and blood tests to see how these cells are activated. The goal is to better understand the disease, not to test a new treatment. …

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study follows 100 stroke survivors with arm weakness to see how their own sense of arm use changes during intensive rehab. Researchers compare patients' perceptions with actual arm function using standard tests. The goal is to better understand the gap between what patients …

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study compares two techniques for guiding a needle into a blocked leg artery from the opposite direction (retrograde). One uses a live X-ray map, the other uses ultrasound. Researchers want to see which is safer and more successful in 32 people with severe leg artery disease…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO. ECMO patients are often sedated and cannot report symptoms, making diagnosis difficult. The device may help doctors diagno…

This study compares standard 2D X-ray imaging with a 3D imaging technique called OCT during leg artery procedures. About 166 adults with blocked leg arteries will be randomly assigned to one of two groups. The goal is to see if OCT helps doctors place stents and inflate balloons …

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study looks at whether using special tools to measure blood flow and take ultrasound images during leg bypass surgery can help predict how well the graft will work over time. It involves 450 people with severe leg artery disease who are having a vein bypass below the knee. T…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…