Limb ischemia

This study is testing a device that uses sound waves to break up calcium buildup in leg arteries of people with chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease. Researchers will track 400 patients to see if the treatment helps wounds heal and …

This study tests a device called the Boomerang Catheter in 120 people with chronic limb-threatening ischemia (CLTI), a severe condition where blocked leg arteries can lead to amputation. The catheter creates a connection between a vein and an artery to reroute blood around the bl…

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This study is following 300 people with peripheral artery disease who received the MicroStent, a small mesh tube placed in leg arteries to improve blood flow. Researchers are tracking how well the arteries stay open over time and whether patients avoid major complications like am…

This study tests a new device called the MOTIV Sirolimus-Eluting Bioresorbable Vascular Scaffold for people with severe leg artery disease (critical limb ischemia). The scaffold slowly releases medicine to keep the artery open and then dissolves over time. Researchers compare it …

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study was designed to test a new surgical technique called transverse tibial bone transport in people with chronic limb-threatening ischemia (CLTI) who have no standard treatment options left. The procedure involves slowly moving a small piece of shinbone to stimulate new bl…

This study tests a new device called the MicroStent, a small mesh tube placed in leg arteries below the knee to keep them open. It involves 177 adults with severe peripheral artery disease who have pain at rest or non-healing sores. Half get the stent plus standard balloon treatm…

This study follows about 200 people with chronic limb-threatening ischemia (CLTI) who receive the Esprit BTK System, a dissolvable scaffold coated with a drug to keep leg arteries open. The goal is to see how safe and effective it is in routine medical practice. Researchers will …

This trial tests a special device called the Esprit BTK, which is a tiny mesh tube coated with a drug that helps keep leg arteries open. It is for people with critical limb ischemia, a serious condition where blocked arteries cause pain and wounds. About 261 participants will rec…

This study compares a special balloon coated with sirolimus (a drug that prevents re-blockage) to a standard balloon for opening blocked arteries below the knee in people with peripheral artery disease. About 230 participants will be randomly assigned to one of the two treatments…

This study looks at a new, less invasive way to remove plaque from leg arteries in people with severe blockages that threaten the limb. About 60 participants will get the procedure, called atherectomy, to see if it can restore blood flow without needing more surgery. The goal is …

This study compares two wound treatments for people with diabetes who have severe foot wounds after leg artery surgery. One group gets standard vacuum therapy, the other gets the same therapy plus a silver nanoparticle spray applied to the wound. The goal is to see which approach…

This study was designed to see if measuring blood flow resistance in tiny leg vessels could predict whether a limb could be saved after artery-opening procedures in people with critical limb ischemia. It planned to enroll patients with severe leg artery disease and use a special …

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study tracks how much of a drug called everolimus enters the blood after placing a special coated device (Esprit BTK) in leg arteries of people with severe blocked leg circulation (critical limb ischemia). About 7 participants will have blood samples taken over 60 days. The …

This study looks at whether adding regular ultrasound scans to standard check-ups helps people who had keyhole surgery for blocked leg arteries. About 70 adults with chronic limb threatening ischaemia will be split into two groups: one gets usual clinic visits, the other gets ext…

This study is collecting information from 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to learn how different treatments affect patients' daily lives and health outcomes. Researchers hope t…