Limb ischemia

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This study tested a temporary stent designed to open blocked arteries below the knee in people with peripheral artery disease or critical limb ischemia. The goal was to improve blood flow and prevent serious complications like amputation. The trial involved 130 participants and m…

This study looked at whether using a very small amount of contrast dye (less than 15 ml) is safe and works for opening blocked leg arteries in 18 patients with both severe leg ischemia and kidney impairment. The goal was to save the leg while protecting the kidneys. Results focus…

This study tested the INDIGO Aspiration System, a device that uses a vacuum to remove blood clots from arteries and veins. It included 500 patients in Japan with acute limb ischemia, mesenteric artery occlusion, or severe deep vein thrombosis. The goal was to confirm the device's…

This study compared angioplasty for one blocked leg artery versus multiple blocked arteries in 40 people with critical limb ischemia, a severe condition that can lead to amputation. The goal was to see which approach better saves limbs and heals wounds. Researchers tracked whethe…

This study tested a new procedure called percutaneous deep vein arterialization for people with critical limb ischemia, a severe form of leg artery disease. The procedure uses a device to create a bypass using a vein, aiming to improve blood flow and prevent amputation. The study…

This study tested a new procedure called percutaneous deep vein arterialization in 34 people with critical limb ischemia, a severe form of blocked leg arteries. The procedure uses a device to create a bypass using a vein, aiming to improve blood flow and prevent amputation. The m…

This early study tested a new tool called the FastWire System in 8 people with severely blocked leg arteries. The goal was to see if the device could safely cross the blockage and allow doctors to place other treatments to restore blood flow. The study focused on safety and wheth…

This study tested a gene therapy called VM202 (Engensis) in 52 people with critical limb ischemia, a severe form of leg artery disease that causes pain and can lead to amputation. Participants received either low-dose, high-dose, or placebo injections into their calf muscles. The…

This early-stage study tested the safety of a gene therapy called VM202 in 12 people with critical limb ischemia, a severe form of leg artery disease causing pain and ulcers. Participants received injections into their leg muscles and were monitored for side effects and pain reli…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This completed study tested a 4-week educational program for 184 people with critical limb ischemia, a severe form of peripheral artery disease that can lead to amputation. The program included group sessions, digital materials, and peer support to teach patients about their cond…

This study tested whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific points on the body, can lower anxiety in people recovering from foot wound surgery. Sixty adults who had surgery for a foot ulcer took part. Researchers measured their anxiety…

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This study looked at a molecule called microRNA-210 in 230 people with peripheral artery disease (PAD), a condition where leg arteries become blocked. Researchers measured its levels and linked them to oxidative stress and walking ability. The goal was to understand how this mole…

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…