Experimental gene injection aims to save limbs from amputation

NCT ID NCT01064440

Summary

This study tested whether injections of an experimental drug called VM202 (Engensis) into the calf muscle could help people with severe blockages in their leg arteries, a condition called critical limb ischemia. The goal was to see if the drug could safely promote new blood vessel growth, improve blood flow, reduce pain, and help prevent the need for leg amputation. The trial involved 52 participants and compared the drug against a placebo injection.

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Contacts and locations

Locations

  • Boston University School of Medicine

    Boston, Massachusetts, 02118, United States

  • Cardiology PC

    Birmingham, Alabama, 35211, United States

  • Ewha Womans University Medical Center

    Seoul, YangCheon-ku, 158-710, South Korea

  • Jobst Vascular

    Toledo, Ohio, 43506, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • Saint Louis University

    St Louis, Missouri, 63110, United States

  • Seoul National University

    Seoul, Jongno-gu, 110-744, South Korea

  • St. Vincent Medical Group

    Indianapolis, Indiana, 46290, United States

  • Texas Heart Institute

    Houston, Texas, 77030, United States

  • The Methodist Hospital

    Houston, Texas, 77030, United States

  • UNC School of Medicine

    Chapel Hill, North Carolina, 27599, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55454, United States

  • University of Oklahoma HSC

    Oklahoma City, Oklahoma, 73104, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

  • Vascular and Interventional Specialist of Orange County

    Orange, California, 92868, United States

  • Yonsei University Health System. Severance Cardiovascular Hospital

    Seoul, Seodaemun-gu, 120-752, South Korea

Conditions

Explore the condition pages connected to this study.