Gene therapy injection shows promise for leg pain from blocked arteries
NCT ID NCT01064440
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 28 times
Summary
This study tested a gene therapy called VM202 (Engensis) in 52 people with critical limb ischemia, a severe blockage of leg arteries causing pain and risk of amputation. Participants received injections into the calf muscle to see if it safely improves blood flow and reduces pain. The goal was to manage the disease and ease symptoms, not to cure it.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston University School of Medicine
Boston, Massachusetts, 02118, United States
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Cardiology PC
Birmingham, Alabama, 35211, United States
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Ewha Womans University Medical Center
Seoul, YangCheon-ku, 158-710, South Korea
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Jobst Vascular
Toledo, Ohio, 43506, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Saint Louis University
St Louis, Missouri, 63110, United States
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Seoul National University
Seoul, Jongno-gu, 110-744, South Korea
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St. Vincent Medical Group
Indianapolis, Indiana, 46290, United States
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Texas Heart Institute
Houston, Texas, 77030, United States
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The Methodist Hospital
Houston, Texas, 77030, United States
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UNC School of Medicine
Chapel Hill, North Carolina, 27599, United States
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University of Minnesota
Minneapolis, Minnesota, 55454, United States
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University of Oklahoma HSC
Oklahoma City, Oklahoma, 73104, United States
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University of Utah
Salt Lake City, Utah, 84132, United States
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Vascular and Interventional Specialist of Orange County
Orange, California, 92868, United States
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Yonsei University Health System. Severance Cardiovascular Hospital
Seoul, Seodaemun-gu, 120-752, South Korea
Conditions
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