Can Metal-Stripping infusions save diabetic limbs and hearts?
NCT ID NCT03982693
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 participants receive the active chelation infusion; the other half receive a placebo (salt water). The study aims to see if cleaning out environmental metals can improve outcomes in this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- edetate disodium (chelation therapy)
- What this could lead to
- If it works, this could offer a new way to prevent major cardiovascular events and amputations in diabetic patients with severe leg artery disease.
- What could go wrong
- This is a relatively small phase 3 trial, and chelation therapy is controversial with mixed prior results. It may not prove effective or could cause side effects from the infusion components.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
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