Stem cells injected before amputation aim to prevent further surgery
NCT ID NCT02685098
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet to prove the treatment works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- allogeneic bone marrow derived mesenchymal stem cells
- What this could lead to
- If it works, this could reduce the need for repeat amputations and improve healing after surgery.
- What could go wrong
- This is an early phase 1 trial focused on safety, not effectiveness. The results may not lead to a standard treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Indiana University
Indianapolis, Indiana, 46202, United States
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