AMPUTATION

This study is testing a new way to perform arm amputations. The goal is to help patients better control advanced prosthetic arms and regain a sense of where their limb is in space. Researchers will compare the new surgery in 10 patients to traditional amputations in 10 others. Th…

This study is testing whether a virtual training system called MyoTrain helps people with arm amputations learn to control their prosthetic devices better. Sixteen participants will use either the MyoTrain system or standard training methods before receiving their actual prosthet…

This early study is testing whether tiny electrode arrays implanted in the nerves of the arm can help people with amputations control a prosthetic hand more naturally. The goal is to record signals from the brain to move the hand and also send artificial touch and position sensat…

This study is testing new powered prosthetic legs that use artificial intelligence to adapt to different activities like walking, climbing stairs, and standing up. Researchers are developing control systems that make the prosthetic knee and ankle move more naturally by learning f…

This study is testing a new surgical technique for people who have already had a leg amputation. The surgery aims to modify the remaining limb to allow for better control of advanced prosthetic limbs, restore the sense of where the limb is in space (proprioception), and potential…

This study is testing an investigational surgery called a hand transplant. It aims to restore function, appearance, and feeling to the hands and forearms of adults who have lost them due to traumatic injury. The procedure transfers tissue from a deceased donor. Researchers will c…

This study is testing whether taking antibiotic pills by mouth for 6 weeks works as well as receiving antibiotics through an IV drip to treat infected bone fractures that have not healed after surgery. It will involve 250 adults who have this complication. The goal is to see if t…

This study is testing if treating a finger amputation with a special, semi-occlusive bandage works as well as or better than surgery. Researchers will randomly assign adult patients with a single finger amputation to receive either the bandage treatment or an operation. The main …

This study is testing a special robotic prosthetic foot that can mimic different commercial feet. The goal is to let veterans with below-knee amputations quickly 'test-drive' various foot designs in a clinic to see which one gives them the best stability and confidence, potential…

This study is testing a new implanted device called MIRA to see if it helps people with a hand amputation control a robotic limb better. The small device is placed under the skin in the remaining forearm muscles to pick up electrical signals, aiming for more natural and simultane…

This study is testing three different nerve surgery techniques to see which works best for reducing chronic pain and phantom limb pain in adults who have had an amputation due to cancer. Participants will be randomly assigned to receive one of the surgical procedures. Researchers…

This study aims to find out if newer, battery-powered prosthetic knees help people with above-knee amputations walk more and feel more confident than the standard mechanical knees they currently use. Researchers will have 26 participants try three different knee models at home fo…

This study is testing a new hybrid pump designed to hold a prosthetic limb more securely and comfortably on a person's residual limb. Researchers will have 20 people who use a prosthetic leg walk on a treadmill to see how the new pump performs. The goal is to see if this new desi…

This study is testing whether small implanted electrodes can help lower limb amputees feel sensations from their missing foot and leg. Researchers will implant electrodes on nerves in the residual limb to send electrical signals that mimic natural sensations. Participants may als…

This study is testing whether prosthetic knees with built-in computers can help reduce falls and improve mobility for people who use above-knee artificial legs. Researchers will compare 100 adults who receive either a standard prosthetic knee or a computer-controlled 'smart' knee…

This study is evaluating a mobile workshop called Breizh Fabribus that uses 3D printing and laser cutting to create custom assistive devices for people with disabilities. It will follow 70 people in France who receive a device to see if it helps them perform daily activities more…

This study is testing whether injecting a person's own skin cells into the skin covering their amputated leg can make that skin firmer and more durable. The goal is to improve comfort and function for people who use a prosthetic leg. Twenty adults with a below-the-knee amputation…

This study is testing whether using artificial intelligence (AI) during walking practice can help people who have had a leg amputated above the knee. It will involve 40 participants and will measure if the AI-guided training improves their balance and stability while walking. The…

This study is testing a new training program designed to help people who use a prosthetic leg walk more confidently. It compares walking on flat surfaces to walking on uneven, bumpy surfaces to see which is better for improving balance and mobility. The goal is to develop better …

This study is comparing two ways to control a prosthetic arm to see which one is more intuitive and less mentally demanding for daily tasks. Researchers are testing a newer 'pattern recognition' system against the standard 'direct control' method with 32 adults who have a below-e…

This registry aims to track how well freezing nerves during an amputation surgery helps manage pain after the operation, including phantom limb pain. It will follow 2,000 adults who are having an amputation. The main goal is to see how the nerve-freezing procedure is used and to …

This study is testing a new body-powered prosthetic hand attachment designed to improve grasping ability for people who have lost an arm or hand. Researchers will compare the new device's performance to current standard prosthetic hooks by measuring how quickly and easily partici…

This study aims to understand the differences between two advanced types of prosthetic hands for people with arm amputations. Researchers will compare bionic hands and myoelectric hands to see which type helps people perform daily tasks better and feel more satisfied with their b…

This study aims to understand how the stiffness of a prosthetic foot affects people with below-knee amputations. Researchers will test three different foot stiffness levels on 60 participants to see how it impacts their walking, balance, pain, and the stress on their bone implant…

This study aims to find the best way to set up muscle sensors so that prosthetic arms respond more naturally to a user's intentions. Researchers are testing different numbers of sensors and sensor placements on 32 adults who have a below-elbow limb difference. Participants will t…

This research aims to understand how our sense of touch works by studying nerve signals in healthy people and some amputees. The goal is to use this knowledge to create prosthetic limbs that can provide realistic sensory feedback, like feeling texture or temperature. Researchers …

This study aims to understand how people with leg amputations move around their communities using both prosthetic limbs and wheelchairs. Researchers will track 50 participants' daily movements using GPS and activity monitors for 10-21 days, while also asking questions about their…

This study is creating a national registry to collect real-world information from 2,000 people who use artificial legs. Researchers will track patient characteristics, device types, and long-term outcomes during regular clinic visits. The goal is to understand how different prost…

This study aims to understand how common nerve pain is in children and teenagers who have had a limb amputated. Researchers will observe 50 participants, asking them questions about phantom limb pain, residual limb pain, and how it affects their daily life and independence. The g…