AMPUTATION

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study tests whether injecting a person's own skin cells from the palm or sole into their amputation stump can thicken the skin and reduce breakdown. Researchers will enroll 50 adults with below-knee amputations who use a prosthetic. The goal is to see if this treatment is sa…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This early study tests whether small implants placed on nerves in the thigh can help people with above-knee amputations control a robotic leg more naturally and feel sensations from it. Three participants will undergo surgery to create regenerative nerve interfaces and have elect…

This early study tests whether tiny electrode arrays implanted in the arm nerves of three amputees can record nerve signals and provide sensory feedback. The goal is to let users control a prosthetic hand more naturally and feel touch or movement. The device is still experimental…

This study tests a new device called MIRA, which is implanted under the skin to pick up electrical signals from muscles in the arm. These signals are then used to control a robotic prosthetic hand. The trial involves 5 adults with a below-elbow amputation who will use the device …

This study tests whether a semi-occlusive dressing (a special film changed weekly) works better than surgery for treating single fingertip amputations in adults. About 252 participants will be randomly assigned to either dressing or standard surgery. The main goal is to see which…

This study is testing whether a hand transplant from a deceased donor can help people who have lost part or all of one or both hands and forearms regain better function, appearance, and feeling. Participants will receive the transplant surgery and be followed closely with exams, …

This study tests a new surgical procedure for people who have had a leg amputated. The surgery builds special connections between muscles to help the brain better control the remaining limb and restore a sense of position and movement. Researchers will enroll 26 adults who alread…

This study tests a new way to perform arm amputations that may allow people to better control advanced prosthetic arms and even feel where their limb is in space. Twenty participants will be split into two groups: ten will get the new surgery, and ten will have a standard amputat…

This study is tracking how well freezing nerves during amputation surgery works to reduce pain after the operation and phantom limb pain. Researchers will follow 2000 adults who are having an arm or leg amputated. The goal is to see if this nerve-freezing technique is safe and he…

This study tests whether a walking program on uneven surfaces can improve walking skill and confidence for people who use a lower-limb prosthesis. Thirty-five adults with leg amputations will practice walking on flat and uneven treadmills for four weeks. Researchers will measure …

This study compares a new myoelectric control strategy called Glide to the standard Direct Control method for upper limb prostheses. Seven adults with below-elbow amputations will use both systems over 24 weeks to see which offers better function, satisfaction, and ease of use. T…

This study is testing whether adding a psychologist and a physical therapist to the usual care of people having a leg amputation can improve their physical and emotional recovery. About 40 adults who need a lower-leg amputation due to poor blood flow will be randomly assigned to …

This study tests a new prosthetic foot system for women veterans with below-knee amputations. The device uses 3D-printed feet that can be swapped to fit different shoes, giving users more footwear options. Researchers want to see if this improves body image and social participati…

This study tests whether small electrical currents delivered to nerves in the leg can restore sensation of a missing foot or limb in 15 adults with above- or below-knee amputations. Participants may also get muscle implants to help control a robotic leg. The goal is to improve wa…

This study looks at whether a prosthetic knee with a built-in computer (microprocessor-controlled) can help people with above-knee amputations have fewer fall-related problems, walk faster, and feel better overall. About 100 adults who already use a basic prosthetic knee will eit…

This study tests whether artificial intelligence can improve gait training for people who have had an above-knee amputation. Forty participants will use AI-guided training to improve their balance and walking stability. The goal is to see if this technology leads to better outcom…

This study tests a virtual training system called MyoTrain for people who have lost part of an arm. Sixteen participants will either use MyoTrain or standard mental practice to learn controlling a prosthetic hand. The goal is to see if MyoTrain helps them use their prosthesis mor…

This phase 2 trial is testing whether injecting a person's own skin cells into the residual limb can improve skin firmness for amputees who use a prosthetic. Twenty adults with a below-knee amputation will receive either the cell injection or a placebo. Researchers will monitor s…

This pilot study tests two surgical methods—targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI)—alone and together to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned …

This study is testing a 'Smart Hallway' system that uses sensors to measure how people walk. Researchers want to see if it is accurate and easy to use in clinics. About 100 people with amputations or walking problems will walk through the hallway as part of their regular rehab. T…

Researchers at MIT are testing a powered ankle prosthesis that uses nerve signals for control and provides skin sensations to the user. Ten people with below-knee amputations will compare this bionic ankle to their regular prosthetic during walking and other tasks. The goal is to…

This study compares two methods for controlling a prosthetic arm: direct control (using signals from two muscles) and pattern recognition (using signals from several muscles to better understand the user's intended movement). Researchers want to see which method is easier to use …

This study aims to understand how people with a lower limb amputation move around in their community, including both walking with a prosthetic and using a wheelchair or scooter. Researchers will give 50 participants a GPS tracker and an activity monitor to wear for 10-21 days to …

This study looks at how the stiffness of a prosthetic foot affects people who have a leg amputation below the knee and use a bone-anchored limb or a standard socket. Researchers will measure bone stress, walking ability, pain, and fall risk as participants walk on different types…

This study looks at how people with a leg amputation adjust their walking patterns. Researchers will measure body movements, muscle activity, and balance in 75 participants while they walk on different surfaces. The goal is to better understand these adaptations, which could help…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers as they touch different surfaces, temperatures, and textures. Researchers will also test how emotions and age affect touch. The goal is to use this knowledge to create pros…

This study looks at children and teens who had a limb removed before age 15-16 to see if they experience nerve pain (phantom limb or stump pain). Researchers will review medical records and use questionnaires during regular check-ups. The goal is to better understand how common t…

This study aims to make powered prosthetic legs for above-knee amputees move more naturally by using machine learning to model how healthy joints work. Researchers will test the new control system in 40 participants, including both able-bodied individuals and those with amputatio…

This study compares two types of artificial hands—bionic and myoelectric—for people who have lost an arm below the shoulder. Researchers want to see which hand helps with daily tasks, how users feel about their body image, and how satisfied they are. About 20 adults who have used…

This study looks at a mobile workshop called Breizh Fabribus that uses 3D printing and laser cutting to make custom assistive devices on the spot for people with disabilities in a region of France. Researchers will track 70 people who received a device to see if it helps them do …

This study is creating a large registry of 2000 people who use lower-limb prostheses. Researchers will collect standard care data, including patient profiles, device details, and long-term outcomes. The goal is to better understand how different devices perform and how patients f…

This study is testing whether a brief 'test-drive' of different prosthetic feet can help veterans with below-knee amputations find the one that gives them the best stability and balance. About 100 veterans will try out several prosthetic feet in a lab and then wear each one at ho…

This study aims to find the best way to place sensors on a prosthetic socket to improve how well people with below-elbow amputations can control their powered arm. Researchers will compare different numbers of sensors (4, 8, or up to 16) and whether targeting specific muscles hel…

This study tests whether powered prosthetic knees help people with above-knee amputations walk more and feel more confident than standard non-powered knees. Twenty-six adults who already use a mechanical knee will try both types at home for three months each. Researchers will tra…