AMPUTATION

This study tests a new device implanted under the skin that picks up muscle signals to control a robotic hand. Five adults with a hand or forearm amputation will have the device placed for up to one year. The goal is to see if it works better than current skin-stuck electrodes an…

This study is testing whether injecting a person's own skin cells into their residual limb can make the skin firmer and healthier. It involves 20 adults with a below-knee amputation who already use a prosthetic. Half will get the cell injections, and the other half will get a pla…

This study tests a new way to perform arm amputations that may allow people to better control advanced prosthetic devices and even feel where their limb is in space. Researchers will perform the new surgery on 10 patients and compare them to 10 others who had standard amputations…

This study tests a system called MyoTrain that helps people who have lost part of their arm learn to control a prosthetic hand using muscle signals. Sixteen participants will either use MyoTrain or standard mental practice before getting their prosthetic. The goal is to see if My…

This study tests a tiny electrode array implanted in the arm nerves of 3 people with arm amputations. The goal is to see if the implant can record nerve signals to control a prosthetic hand and also provide a sense of touch. Participants must be between 18 and 65 and have a below…

This study tests whether a hand transplant from a deceased donor can improve function, appearance, and sensation in people who have lost part or all of one or both hands or forearms due to injury. Up to 100 adults aged 18 to 60 will receive the transplant and be followed with exa…

This study tests a new surgical technique for people who have had a leg amputation below or above the knee. The goal is to help them gain better control over their residual limb muscles, restore a sense of where the limb is in space (proprioception), and reverse muscle wasting. T…

This study tests whether taking antibiotic pills for 6 weeks works as well as getting IV antibiotics for infected bone fractures that didn't heal properly. About 250 adults with this condition will be randomly assigned to either oral or IV antibiotics, along with surgery. The goa…

This study compares computer-controlled prosthetic knees (MPKs) to standard ones in 100 adults with above-knee amputations. The goal is to see if MPKs reduce fall-related health problems, improve mobility, and boost quality of life. Participants keep their current knee or receive…

This study looks at whether using a special clear dressing alone can work as well as surgery for people who have lost the tip of a finger. About 252 adults with a single fingertip amputation will be randomly assigned to either get surgery or have the wound covered with a semi-occ…

This study looks at whether a mobile workshop called Breizh Fabribus can help people with disabilities by making custom assistive devices on the spot using 3D printing and laser cutting. About 70 people who received a device will be asked how often they face their main difficulty…

This study is tracking how well freezing nerves during amputation surgery works to reduce pain after the operation and phantom limb pain. Researchers will watch 2000 adults who are having an arm or leg removed. The goal is to see if this nerve-freezing technique is safe and helps…

This study tests whether artificial intelligence can improve walking stability in people who have had an above-knee amputation. Researchers will measure balance and stability in 40 participants as they train with AI-guided gait exercises. The goal is to see if AI can help make wa…

This study tests a new type of prosthetic hook that aims to give people with upper limb loss a better grip without the usual trade-offs. Eight adults aged 18 to 80 will compare the new device to standard hooks by doing everyday tasks like picking up objects. The goal is to see if…

This study tests a walking program on uneven ground for people with a lower-limb prosthesis. The goal is to see if practicing on varied surfaces can improve walking skill and confidence. Researchers will enroll 35 adults who regularly use a prosthetic leg.

This study tests a new type of prosthetic foot that can change shape to fit different shoes, giving women veterans with below-knee amputations more footwear choices. Researchers want to see if having more shoe options improves body image and helps them take part in more social ac…

This study tests whether small electrical currents delivered to nerves in the leg can restore sensation of a missing foot or limb in 15 adults with above- or below-knee amputations. Participants may also get muscle implants to help control a robotic leg. The goal is to improve wa…

This study compares two approved surgical techniques, TMR and RPNI, used alone or together to reduce long-term pain in the remaining limb and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three surgery groups.…

This study looks at how well bionic and myoelectric hands work for people who have lost an arm. Researchers will measure hand function, body image, and user satisfaction in 20 adults who use a prosthetic hand regularly. The goal is to find out if one type of hand helps people fee…

This study is for adults with a leg amputation above the knee who currently use a mechanical (non-powered) knee. Researchers want to see if a powered knee helps them walk more and feel more confident. Participants will try both types of knees at home for three months each, and th…

This study is creating a large database of people who use a lower-limb prosthesis (artificial leg). Researchers will collect information about the patients, their devices, and how they do over time. The goal is to better understand different patient groups and how well different …

This study compares two methods of controlling a prosthetic arm for adults with below-elbow limb loss. One method uses signals from two muscles, while the other uses signals from several muscles to better understand the user's intended movement. The goal is to see which method is…

This study aims to understand how people with a leg amputation move around outside their homes, including both walking and using wheelchairs or scooters. Researchers will track 50 participants for 10-21 days using GPS and activity monitors, along with questionnaires about quality…

This study looks at how the stiffness of a prosthetic foot affects people who have a bone-anchored limb after a below-knee amputation. Researchers will have 60 participants walk and do daily tasks with different foot stiffness levels to measure bone-implant stress, function, pain…

This study aims to see if letting veterans with below-knee amputations briefly try different prosthetic feet can help predict which foot will give them the best stability and balance confidence. Up to 100 participants will test several feet in a lab and then wear each one at home…

This study looks at how people adjust their walking after losing part of a leg. Researchers will measure movement, balance, and muscle activity in 75 adults with a leg amputation while they walk on different surfaces. The goal is to better understand these changes to improve futu…

This study looks at how changing the number and placement of sensors on a prosthetic arm affects how well people with below-elbow amputations can control it. About 32 adults who already use a myoelectric (muscle-signal) prosthetic will test different sensor setups while doing tas…

This study aims to make powered prosthetic legs for above-knee amputees move more naturally by using machine learning. Researchers will collect data from people without amputations to create a model that helps the prosthetic leg adapt to different activities like walking, stairs,…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers. Researchers will use tiny needles and various stimuli to learn how the skin and nerves send touch information to the brain. The goal is to use this knowledge to create pro…

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…