Can freezing nerves stop phantom limb pain?

NCT ID NCT06908538

Recruiting now Symptom relief Sponsor: AtriCure, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is tracking how well freezing nerves during amputation surgery works to reduce pain after the operation and phantom limb pain. Researchers will follow 2000 adults who are having an arm or leg amputated. The goal is to see if this nerve-freezing technique is safe and helpful.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoablation (nerve freezing via a probe)
What this could lead to: If successful, this could provide a way to reduce severe pain after amputation, including phantom limb pain, without long-term medication.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove the treatment works. The nerve block is temporary (weeks to months), and pain may return. Risks include procedural complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AMPUTATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION AMPUTATION OF LOWER LIMB AMPUTATION OF UPPER LIMB AMPUTATION, LIMB LOSS AMPUTATION, TRAUMATIC/SURGERY CRYO ANALGESIA

Contacts and locations

Locations

Berkshire Medical Center
RECRUITING

Pittsfield, Massachusetts, 01201, United States
Elliot Hospital
RECRUITING

Manchester, New Hampshire, 03101, United States
Medical College of Wisconsin/Froedtert Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
NYU Langone Health
RECRUITING

New York, New York, 10017, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.