Can freezing nerves stop phantom limb pain?
NCT ID NCT06908538
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is tracking how well freezing nerves during amputation surgery works to reduce pain after the operation and phantom limb pain. Researchers will follow 2000 adults who are having an arm or leg amputated. The goal is to see if this nerve-freezing technique is safe and helpful.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cryoablation (nerve freezing via a probe)
What this could lead to
If successful, this could provide a way to reduce severe pain after amputation, including phantom limb pain, without long-term medication.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove the treatment works. The nerve block is temporary (weeks to months), and pain may return. Risks include procedural complications.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Berkshire Medical Center
RECRUITINGPittsfield, Massachusetts, 01201, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Elliot Hospital
RECRUITINGManchester, New Hampshire, 03101, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Medical College of Wisconsin/Froedtert Hospital
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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NYU Langone Health
RECRUITINGNew York, New York, 10017, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••