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Rerouting nerves during amputation may stop phantom pain before it starts

NCT ID NCT05408520

Symptom relief Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether a surgical technique called targeted muscle reinnervation (TMR) can reduce nerve pain and phantom limb pain after a leg amputation. TMR reroutes severed nerves to nearby muscle nerves to encourage organized regrowth. Adults scheduled for a below- or above-knee amputation will be randomly assigned to receive either standard amputation or amputation plus TMR, and their pain levels will be compared over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a surgical procedure called targeted muscle reinnervation (TMR) that reroutes severed nerves to nearby muscle nerves to encourage organized regrowth
What this could lead to
If it works, this could become a standard surgical technique to prevent chronic nerve pain and phantom limb pain after leg amputation.
What could go wrong
This is a single-center trial with a small planned enrollment, so results may not apply broadly. The procedure adds surgical complexity and carries typical surgical risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Apr 2022

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Any individual 18 years and older indicated for a below knee or above knee amputation at Banner-University Medical Center Phoenix Exclusion Criteria: * Any individual who does not meet inclusion criteria

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Conditions

The condition(s) this trial relates to.

neuroma Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation

Contacts and locations

Locations

  • Banner - University Medical Center, Phoenix campus

    Phoenix, Arizona, 85006, United States

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