University Of Arizona

This trial tests whether filling the bone gap left after ACL reconstruction with a patient's own bone or a processed bone product leads to better outcomes. Adults aged 18-40 undergoing ACL surgery with a bone-patellar tendon-bone graft will be randomly assigned to receive either …

This trial tests whether Angiotensin (1-7), a synthetic version of a natural protein fragment, is safe and effective for people with moderate to severe traumatic brain injury (TBI). Participants receive a daily injection for 21 days, along with blood tests, MRI scans, and cogniti…

This trial compares two ways to guide ablation for ventricular tachycardia, a dangerous fast heart rhythm. One method uses standard voltage mapping to burn away all low-voltage scar tissue. The other uses a newer technique called ILAM that targets specific zones where the electri…

This study tests whether adding the drug tarlatamab to standard radiation therapy is safe for people with cancers that have a protein called DLL3, including melanoma, lung cancer, and glioblastoma. About 30 adults with advanced or returning cancers will receive tarlatamab infusio…

This trial tests whether apixaban, a newer blood thinner with fixed dosing, works as well as warfarin for dissolving dangerous blood clots in the heart's main pumping chamber. Adults with a confirmed left ventricular thrombus are randomly assigned to receive either apixaban or wa…

This trial tests whether a training program for methadone clinic staff can help patients stay in treatment longer and reduce overdose risk. The program focuses on trauma-informed, patient-centered care and includes staff education, supervision, and clinic self-assessment. Researc…

This study tests whether a simple breathing exercise, called Inspiratory Muscle Strength Training (IMST), can safely lower blood pressure in pregnant women during their third trimester. Participants do 5 to 8 minutes of breathing against light or moderate resistance each day for …

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their indivi…

This study tests whether a community health worker-led program can help Mexican-origin adults with fatty liver disease (MASLD) better understand their heart disease risk and make healthier lifestyle changes. About 45 participants and their family members or friends will take part…

This study tests whether omega-3 supplements can reduce inflammation and improve heart health differently depending on a person's genetic makeup and ancestry. Two hundred healthy adults of African or European descent will take omega-3s or a placebo for 12 weeks each, then switch.…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication schedule. One hundred participants will use either the full app with reminders or just the education part for …

This study tests a special PET/CT scan using a tracer called 18F-Fluciclovine to see if it can better detect brain metastases and tell them apart from changes caused by earlier treatments. About 20 adults with known or suspected brain metastases will get the scan before and after…

This study tests a combination of tools—video messages, mailed stool test kits, and help with social needs—to encourage colorectal cancer screening among Latinx adults aged 45-64. About 6000 participants will receive these supports, and researchers will compare screening completi…

This study tests whether adding telephone health coaching to a symptom management handbook helps reduce symptom burden and improve quality of life for people with metastatic breast, GI, or melanoma cancer and their caregivers. About 200 participants will be split into two groups:…

This study compares word learning in late-talking toddlers (ages 2–3) who receive a behavioral treatment called VAULT. One group is taught words from categories they already know (like animals), while the other group learns words from less familiar categories. The goal is to see …

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) manage stress and recover better after total knee replacement. Thirty-two participants will be randomly assigned to either the breathing exercise or a control activity.…

This study tests a drug called Pedmark (sodium thiosulfate) to see if it can prevent hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 adults will take Pedmark alongside their chemo. The drug is alread…

This study tests a program to help long-term lung cancer survivors feel more socially connected and improve their quality of life. Thirty survivors will be randomly assigned to either the program or a comparison group. The program uses techniques from cognitive behavioral therapy…

This study tests whether adjusting bedtime by just 15 minutes each week can help adults who sleep 6 hours or less get more sleep. Over 1,000 participants will use a sleep diary or Fitbit to guide their schedule. The goal is to see if this simple approach improves sleep duration, …

This study compares 3D-printed ear tips to standard ones for hearing aids in 32 adults with hearing loss. Participants will try each type for a week and rate comfort, sound quality, and fit. Researchers will also measure production time and cost to see if 3D printing is a practic…

This study tests a new brace that applies small, repeated forces to the wrist during sleep, aiming to relieve carpal tunnel syndrome symptoms. Researchers will compare it to a standard brace in 116 adults. The main goal is to see if the device reduces pain and improves hand funct…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study explores whether combining a safe, low-level electrical brain stimulation (tDCS) with online chair yoga can help manage chronic knee pain in older adults with Alzheimer's or related dementias. Forty participants, along with their caregivers, will do 14 supervised sessi…

This study tests whether a 10-day meditation program delivered through a smartphone app can reduce anxiety and depression in firefighters. About 192 career firefighters will either use the meditation app or a health education app for 10 days. Researchers will measure changes in d…

This study compares a personalized caffeine dosing algorithm to standard caffeine gum for maintaining performance during 62 hours of total sleep deprivation. About 180 healthy adults aged 18-39 will complete at-home monitoring and a 4-day lab stay with no sleep. Researchers will …

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. 144 adults with moderate to severe insomnia will receive either real TMS to different brain areas or a sham (inactive) treatment over two weeks. Researchers w…

This study tests whether wearing special glasses that emit blue light each morning for two weeks can improve mood, sleep, and reduce suicidal thoughts in military members with mild depression. Researchers will compare the active blue light to a placebo light to see if the timing …

This study looks at whether it is safe for some patients to go home the same day after colon surgery. Researchers will track 150 adults aged 18-70 who have robotic-assisted colon removal. The main goal is to see how many need to be readmitted within 30 days, along with other comp…

This early-stage study explores whether exercise can improve the quality of immune cells collected from healthy donors for blood cancer treatments. Researchers will have healthy volunteers cycle, take a beta blocker or placebo, or receive a drug that mimics adrenaline, then analy…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study tests whether 3D-printed ear tips are more comfortable and sound better than standard ones. Thirty adults with normal hearing will try both types and rate their comfort, fit, and sound quality. Researchers will also compare the cost and time to make each type. The goal…

This study is testing whether a 3-week program of eating walnuts, supervised exercise, and nutrition counseling is practical for American Indian adults recently diagnosed with cancer. The 30 participants will follow the program before starting their cancer treatment. Researchers …

This study tests whether short-term, strenuous exercise before lung cancer surgery can change the tumor's immune environment. Researchers will compare tumor samples from 48 patients who exercise versus those who don't. The goal is to see if exercise boosts immune-related signals …

This study exposes small areas of sun-damaged skin to simulated sunlight to see how proteins and genes change. Researchers will compare 46 adults—half with a history of skin cancer, half without—to find differences that might explain cancer risk. Participants will have four small…

This study is creating a repository of tumor, tissue, and blood samples from cancer patients. The goal is to store these biospecimens for future research that could improve our understanding of cancer. Up to 10,000 participants will provide samples during their routine care at th…

This study follows 250 patients who are having surgery to remove part of their pancreas due to cancer, pancreatitis, or cysts. Researchers will track changes in quality of life, symptoms, and emotional well-being for up to two years after surgery. The goal is to understand how th…