University Of Arizona

This study looks at whether omega-3 supplements can reduce inflammation and improve heart health differently depending on a person's genetic background. About 200 healthy adults of African or European ancestry will take omega-3 capsules or a placebo for 12 weeks each, then switch…

This study tests whether adding tadalafil (a drug for erectile dysfunction) to standard chemotherapy can help shrink stomach or gastroesophageal junction tumors before surgery. Ten adults with resectable cancer will take tadalafil alone for two weeks, then combined with chemo for…

This study tests whether a natural brain hormone called allopregnanolone can safely slow or reverse memory loss in people with early-stage Alzheimer's. About 100 adults aged 55-80 will receive either the drug or a placebo for several months. The main goal is to see if the drug ca…

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder for people with non-muscle invasive bladder cancer. The goal is to control the cancer and prevent it from coming back, potentially avoiding the need for bladder re…

This study tests whether a community health worker-led program can help Mexican-origin adults with fatty liver disease (MASLD) improve heart health and lifestyle habits. About 45 participants will join to see if the program is acceptable and practical. The goal is to reduce heart…

This study tests a team of pharmacists and community health workers (CHWs) to help people with high blood pressure take their medications as prescribed. The goal is to improve medication adherence and lower blood pressure. The study includes 217 adults who identify as African-Ame…

This study tests whether adding a drug called tarlatamab to standard radiation therapy is safe and effective for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and bladder cancers. About 30 adults with advanced or returning cancers will receive …

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication. About 100 participants will use either the full app with reminders or just an education portal for 16 weeks. …

This study tests a special PET scan (18F-Fluciclovine) to see if it can better detect brain metastases and tell them apart from changes caused by earlier treatments. About 20 adults with known or suspected brain metastases will get the scan before and after treatment. The goal is…

This study tests whether a telehealth program, developed with community input, can help more people get screened for colorectal cancer. About 6,000 adults aged 45-64 who are due for screening will receive the intervention. The goal is to see if this approach increases screening r…

This study tests a device worn at night that gently pushes and releases on the wrist to open up space in the carpal tunnel. Researchers want to see if it reduces pain and improves hand function better than standard care. 116 adults with carpal tunnel syndrome will use the device …

This study tests if 3D-printed ear tips are more comfortable and sound better than standard ones for people with hearing loss. Researchers will compare fit, sound quality, cost, and production time in 32 adults with hearing loss in both ears. The goal is to see if 3D printing can…

This study tests whether a 10-day meditation app can lower anxiety and depression in firefighters. About 192 career firefighters will use pre-recorded audio sessions on their smartphones. The goal is to see if this simple, at-home tool can ease the mental strain of their demandin…

This study tests whether a personalized caffeine schedule helps people stay alert and think clearly during 62 hours of total sleep deprivation better than standard caffeine dosing. About 180 healthy adults aged 18-39 will wear activity monitors, do reaction-time tests at home and…

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. Over 2 weeks, 144 adults will receive either real TMS to different brain areas or a sham (fake) treatment. Researchers will monitor sleep at home and in the l…

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness, anxiety, and depression. About 70 adults already receiving mental health treatment will take part. The goal is to see if shared v…

This study tests whether morning light exposure can help regulate mood, improve sleep, and reduce suicidal thoughts in military personnel. Researchers will enroll 480 service members with mild depression or more. Participants will use a light device each morning to see if it impr…

This study tests a program designed to help Hispanics with knee osteoarthritis become more active. Participants pair up with a family member or close friend and receive live video sessions on exercise and education. The goal is to see if this approach improves exercise habits and…

This study looks at whether certain patients can safely go home the same day after colon surgery instead of staying in the hospital. Researchers will track how many patients need to be readmitted within 30 days, along with other complications like infection or bleeding. The goal …

This study tests a personalized approach to treat obstructive sleep apnea (OSA) in people with Down syndrome. Researchers will compare giving everyone the same drug combination (atomoxetine and oxybutynin) versus assigning either that drug or oxygen therapy based on each person's…

This study tests whether a safe, noninvasive brain stimulation technique (tDCS) combined with online chair yoga can help manage chronic knee pain in older adults with Alzheimer's or related dementias. Forty participants aged 60 and older with mild to moderate dementia and chronic…

This study looks at whether a personalized sleep extension program can help adults who regularly get 6 hours or less of sleep per night. Researchers will track sleep duration, tiredness, mental health, and thinking skills using FitBit devices and questionnaires. The goal is to se…

This study looks at whether doing intense exercise for two weeks before lung cancer surgery can change the tumor's surroundings and help the immune system fight better. Researchers will compare people who exercise with those who don't, and check tumor samples for changes. The goa…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) makes people feel more hopeless, have worse decision-making, and experience more suicidal thoughts. Adults who have had suicidal thoughts in the past six months will be tested in a lab and at home …

This study looks at how a small area of skin reacts to simulated sunlight in people who have had skin cancer and those who haven't. Researchers will take tiny skin samples to measure changes in proteins and genes. The goal is to understand why some people get skin cancer and othe…

This study is testing whether a program of eating walnuts and doing moderate exercise before cancer treatment is practical and acceptable for American Indian patients. Researchers will also measure markers of inflammation in blood and tumor tissue to see if the program has an eff…

This study follows 250 adults undergoing pancreatic surgery for cancer, cysts, or pancreatitis. Researchers will track changes in quality of life, symptoms, and emotional well-being for up to two years. The goal is to help doctors and patients have better conversations about what…

This study tests whether 3D-printed ear tips are more comfortable and sound better than standard ones for hearing aids. Thirty adults with normal hearing will try both types. Researchers will measure fit, comfort, cost, and production time to see if 3D printing is a good alternat…

This study collects and stores tumor, tissue, and blood samples from people with cancer. The samples are kept in a secure database and used by researchers to learn more about cancer. Anyone being treated for cancer at the Arizona Cancer Center or University Medical Center can joi…