Smarter caffeine dosing could beat standard gum for All-Nighters
NCT ID NCT05588934
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a personalized caffeine dosing algorithm to standard caffeine gum for maintaining performance during 62 hours of total sleep deprivation. About 180 healthy adults aged 18-39 will complete at-home monitoring and a 4-day lab stay with no sleep. Researchers will measure reaction time, sleepiness, and side effects to see which approach works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
caffeine gum
What this could lead to
If it works, this could provide a smarter way to use caffeine to stay alert during sleep loss, with fewer side effects and better recovery sleep.
What could go wrong
This is an early-stage study with 180 participants, so results may not apply to everyone. The personalized algorithm may not outperform standard dosing, and caffeine can still cause jitters or sleep disruption.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SLEEP DEPRIVATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University of Arizona
RECRUITINGTucson, Arizona, 85719, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Arizona Psychiatry Department
RECRUITINGTucson, Arizona, 85724, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact