Smarter caffeine dosing could beat standard gum for All-Nighters

NCT ID NCT05588934

Recruiting now Symptom relief Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a personalized caffeine dosing algorithm to standard caffeine gum for maintaining performance during 62 hours of total sleep deprivation. About 180 healthy adults aged 18-39 will complete at-home monitoring and a 4-day lab stay with no sleep. Researchers will measure reaction time, sleepiness, and side effects to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: caffeine gum
What this could lead to: If it works, this could provide a smarter way to use caffeine to stay alert during sleep loss, with fewer side effects and better recovery sleep.
What could go wrong: This is an early-stage study with 180 participants, so results may not apply to everyone. The personalized algorithm may not outperform standard dosing, and caffeine can still cause jitters or sleep disruption.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Sleep Deprivation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CAFFEINE SLEEP DEPRIVATION

Contacts and locations

Locations

University of Arizona
RECRUITING

Tucson, Arizona, 85719, United States
University of Arizona Psychiatry Department
RECRUITING

Tucson, Arizona, 85724, United States

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