SLEEP DEPRIVATION

This study looks at whether limiting food intake to 8 hours a day can lower blood pressure and improve blood sugar control in people who habitually sleep 6.5 hours or less per night. Researchers will compare the usual long eating period to a restricted 8-hour eating window over 4…

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study tests if a gentle, non-invasive neck massage (called NSCLD) can improve memory and thinking in adults who are sleep-deprived. Researchers will enroll 30 college students and measure changes in memory, attention, and mood. The goal is to see if this simple technique can…

This study compares a personalized caffeine dosing algorithm to standard caffeine gum for maintaining performance during 62 hours of total sleep deprivation. About 180 healthy adults aged 18-39 will complete at-home monitoring and a 4-day lab stay with no sleep. Researchers will …

This study looks at whether a ketogenic diet or ketone supplements can reduce the mental and physical downsides of sleep loss. Sixty healthy adults ages 18–40 will cut their sleep by half for four nights while following either a ketogenic or Mediterranean diet, and taking either …

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study looks at how getting too little sleep changes the way your heart pumps blood during exercise. Researchers will ask 30 healthy young adults to cycle after a normal night's sleep and again after a night where they wake up early. They want to see if a drop in blood volume…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people process and control their emotions. Researchers will use brain scans and behavioral tests to compare these groups with people who sleep normally. The goal is to bett…

This study looks at how different patterns of light exposure and food intake affect the body's metabolism when sleep is reduced. Researchers will monitor 120 healthy adults aged 18-35 over 4-6 months, including three overnight clinic stays. The goal is to understand how these fac…

This study looks at how a full day without sleep changes certain proteins in the blood that are linked to Alzheimer's disease. Researchers want to see if people with different versions of the APOE gene react differently to sleep loss. The study involves 60 healthy adults aged 18 …

This study looks at how the body's internal clock changes our perception of time when we stay awake for 36 hours. Thirty healthy adults will remain awake in a controlled lab, with constant light, posture, and food. Every two hours, they complete tests on time estimation, reaction…

This study looks at how working a 24-hour shift affects the immune system of surgery residents. Researchers will measure changes in immune cells and inflammation before and after the shift. The goal is to understand the health risks of sleep deprivation in medical professionals.