Earthbound study mimics space stress to protect astronaut brains

NCT ID NCT07293494

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study will put 56 healthy adults aged 25-60 through 27 hours of sleep deprivation and alcohol consumption (to a 0.08% BAC) in a lab over 110 hours. Researchers will measure how these stressors affect thinking, movement, and brain scans. The goal is to better predict and manage similar risks astronauts face during spaceflight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Alcohol (vodka mixed with juice or soda)
What this could lead to: If successful, this could help predict and reduce cognitive and motor risks for astronauts during space missions.
What could go wrong: This is a small, early-stage study in a controlled lab, not in space. Results may not fully apply to real spaceflight conditions.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Sleep Deprivation Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL IMPAIRMENT IMPAIRMENT, COGNITIVE SLEEP DEPRIVATION STRESSOR, INDIVIDUAL

Contacts and locations

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Locations

University of Pennsylvania Perelman School of Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••

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