New ICU sleep therapy aims to reset body clocks in critical illness

NCT ID NCT05551325

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bundle during their ICU stay, and researchers will measure changes in heart rate and melatonin levels.

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Conditions

The condition(s) this trial relates to.

circadian rhythm sleep disorder Critical Illness Sleep Deprivation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCADIAN RHYTHM SLEEP DISORDER, UNSPECIFIED CRITICAL ILLNESS SLEEP DEPRIVATION

Contacts and locations

Locations

Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at St Raphael's Campus
RECRUITING

New Haven, Connecticut, 06520, United States
Yale New Haven Hospital Medical Intensive Care Unit (YNHH MICU) at York Street
RECRUITING

New Haven, Connecticut, 06520, United States

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