Circadian rhythm sleep disorder

This study tests whether using a bright blue light device for 15-30 minutes each morning can slow the progression of idiopathic scoliosis in children aged 10-15 who are night owls. The trial will enroll 120 participants and follow them for 6 months, measuring spine curve changes …

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This study looks at whether time-restricted eating (eating only during certain hours) can improve blood pressure and insulin sensitivity in people who work night shifts. Night shift workers are at higher risk for heart disease and type 2 diabetes. Researchers will compare 4 weeks…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study looks at whether adjusting meal timing can reduce health risks for night-shift nurses and nursing assistants who are overweight. Participants will either just track their diet, follow a 10-hour daytime eating window, or add a low-sugar snack during night shifts. The go…

This study tests whether the drug Lemborexant helps people with delayed sleep phase syndrome fall asleep faster at their desired bedtime. Fifteen adults will take either the drug or a placebo nightly for up to 2 years, tracking sleep with logs and a wrist monitor. The goal is to …

This study tests a combination of sleep-promoting and circadian-aligning treatments (a "sleep chronobundle") in 160 critically ill ICU patients. The goal is to see if realigning the body's internal clock can improve sleep quality and metabolism. Participants will receive the bund…

This study tests whether a low-dose melatonin pill (0.5 mg) combined with a behavioral sleep program can shift the body's internal clock earlier and improve mood in people with bipolar disorder who are night owls. Fifty participants will either get melatonin plus sleep therapy or…

This study tests whether a sleep-focused therapy can improve depression in teenagers whose body clocks are out of sync with their wake-up time. Researchers will enroll 200 adolescents with depression and delayed sleep phase. The therapy aims to realign their internal circadian rh…

This study tests whether taking melatonin can improve sleep quality and duration for medical residents working night float shifts. Fifty residents will be randomly assigned to receive either melatonin or a placebo, and their sleep will be measured with a portable brain-wave monit…

This pilot study tests whether a non-invasive headset that delivers mild electrical stimulation to nerves behind the ear can safely improve sleep in adults who are blind or severely sight impaired. Sixty participants will use the device for 30 minutes a day, five times a week for…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests a brief behavioral sleep program for depressed teens aged 12-18 who sleep less than 7 hours or have irregular sleep. The program uses two sessions and smartphone tools to help teens set sleep goals. Researchers will compare it to a simple sleep education session …

This study tests a mobile app called SHIFT that uses data from an Apple Watch to give personalized light exposure advice, helping night shift workers sleep better. Researchers will enroll 300 night shift workers who have poor sleep. The goal is to see if the app improves sleep, h…

This study tests two wearable devices in 20 people with Alzheimer's and their caregivers in rural Taiwan. One device tracks sleep and activity, while the other uses light therapy to improve sleep and mood. The goal is to see if these tools are easy to use and can help reduce beha…

This study tests whether dynamic light therapy can restore natural sleep-wake cycles in intensive care patients suffering from delirium. Forty adults in the ICU will receive either a special light algorithm or standard hospital lighting. Researchers will measure changes in melato…

This study tests a 4-week online course designed to help adults who experience parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course teaches safety planning, relaxation, and therapy techniques. Researchers will measure whether it reduces h…

This study tests whether a special type of artificial light that changes throughout the day can improve sleep, body clock function, and overall well-being in frail older adults. Researchers will enroll 300 people over age 65 who are staying in hospital rooms equipped with this dy…

This Phase 3 trial tests whether the drug tasimelteon can help people with Delayed Sleep-Wake Phase Disorder (DSWPD) fall asleep earlier and sleep better. 70 adults with DSWPD will receive either tasimelteon or a placebo daily. The study measures sleep onset and quality using sle…

This Phase 3 trial tests whether the drug solriamfetol can reduce excessive sleepiness in people with shift work disorder. About 520 adults who work night shifts will take either solriamfetol or a placebo daily for 12 weeks. The study measures how well they stay awake and their o…

This study tests whether a special memory support program can help people aged 50 and older remember and stick to their sleep treatment. The program uses simple memory strategies alongside standard sleep therapy. Researchers will track sleep quality, daily functioning, and life s…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study investigates whether the match between a person's chronotype (morning or evening preference) and the time of day influences how they perceive time. Healthy adults who are clear morning or evening types complete perception and cognition tasks both early in the morning a…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study aims to understand what causes delayed sleep wake phase disorder (DSWPD), a condition where people's sleep times are shifted later. Researchers will compare 66 participants with DSWPD to healthy controls by measuring body temperature, melatonin, and thinking ability du…

This study looks at how the pupils of people with Delayed Sleep-Wake Phase Disorder react to light. Researchers want to see if there are differences in light sensitivity and whether a single dose of citalopram (a serotonin-boosting drug) can increase melatonin suppression during …

This study aims to understand how working night shifts impacts blood sugar, fat levels, and heart health in hospital staff. Researchers will compare workers who do night shifts with those who don't, using continuous glucose monitors and other measurements. The goal is to gather k…

This study looks at whether taking a nap during a night shift can improve blood pressure and alertness in healthcare and public safety workers. Researchers will compare naps lasting 0, 15, 30, 45, or 60 minutes taken at 2:00 AM. The goal is to find the nap length that best balanc…

This study aims to understand how the light from tablet screens and the type of content children watch before bed affect their sleep, thinking skills, and emotions. Researchers will have 220 children aged 8 to 11 spend one hour before bed either using a bright tablet, a dim table…

This study looks at whether being awake during the late-night hours (2:00-4:00 AM) can worsen mood, increase hopelessness, and impair decision-making in people who have had suicidal thoughts in the past six months. Researchers will monitor 90 adults in a lab and at home under dif…

This study looks at whether giving light therapy to critically ill children (ages 4-17) in the pediatric ICU is practical and well-tolerated. Each morning, a light box is placed at the bedside, and light levels are measured. Children, families, and staff fill out surveys about th…

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This Stanford study watches 20 young women for 28 days to see how sleep, body rhythms, and the menstrual cycle work together. Researchers track movement, heart rate, and other body signals. The goal is to learn how these cycles might affect injury risk, not to test a treatment.

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at how cannabis use and stopping it affect sleep, daily body rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users with non-users using sleep monitors, light tests, and pupil measurements. The goal i…

This study tests whether it is possible to measure and improve sleep and body clock rhythms in children aged 3 to 6 who are in the pediatric intensive care unit (PICU). Researchers will use a watch-like device and saliva tests to track sleep, and try two simple approaches: bright…

This study aims to improve how sleep is measured for nightshift workers, whose inverted schedules make standard sleep trackers inaccurate. Researchers will use an Apple Watch along with machine learning to better detect daytime sleep. About 100 nightshift workers will participate…

This study looks at whether working unusual hours or having idle time at work makes people more likely to gamble in risky ways. Researchers will interview 25 adults who currently have or have had gambling problems and who have worked in the past year. The goal is to understand ho…

This study from Uppsala University looks at how a low-fat, fiber-rich diet versus a high-fat, Western-style diet affects sleep quality, heart rate, and metabolism. Twenty-four healthy young adults will follow each diet for about a week, then spend two days in the lab for detailed…

This study looks at whether providing meals to night-shift EMS workers can help them keep steady blood sugar levels. Forty participants will receive a meal service and track their glucose and stress. The goal is to see if this approach is practical and worth testing in a larger t…

This study looks at how different patterns of light exposure and food intake affect the body's metabolism when sleep is reduced. Researchers will monitor 120 healthy adults aged 18-35 over 4-6 months, including three overnight clinic stays. The goal is to understand how these fac…

This study looks at how being a 'morning person' or 'night owl' changes the way you experience time. Healthy adults aged 23-45 will do computer tasks at their preferred time of day and again at the opposite time. Researchers want to see if time judgments and alertness are worse w…

This study looks at how the body's internal clock changes our perception of time when we stay awake for 36 hours. Thirty healthy adults will remain awake in a controlled lab, with constant light, posture, and food. Every two hours, they complete tests on time estimation, reaction…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire (SRQ), a tool that measures how consistent a person's sleep schedule is. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders, who will fill out the q…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study looks at how eating a high-fat diet can change your body's internal clock, which controls sleep and other daily rhythms. Researchers will track 14 healthy, lean adults over 46 days, including 18 days spent in a research center. The goal is to understand how quickly the…

This study looks at whether a person's tendency to have trouble sleeping when stressed (called sleep reactivity) is a main cause of Shift Work Disorder. Researchers will reduce the mismatch between workers' body clocks and their nightshift schedule, then see if those with high sl…

This study aims to understand why night shift work is linked to obesity. Researchers will compare 1000 night shift and day workers across five European countries, measuring body composition, diet, and biological markers like hormones and inflammation. The goal is to uncover the m…