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Can a night owl pill fix bipolar mood swings?

NCT ID NCT06226025

Recruiting now Symptom relief Sponsor: Leslie Swanson Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a low-dose melatonin pill (0.5 mg) combined with a behavioral sleep program can shift the body's internal clock earlier and improve mood in people with bipolar disorder who are night owls. Fifty participants will either get melatonin plus sleep therapy or a placebo plus a control sleep session. The goal is to see if this approach reduces depressive symptoms and advances the timing of melatonin onset.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Melatonin (0.5 mg daily oral pill)
What this could lead to
If it works, this could point toward a simple, low-cost way to improve mood and sleep in people with bipolar disorder who are night owls.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply widely. Melatonin is generally safe but may not shift sleep timing enough to help everyone.

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Conditions

The condition(s) this trial relates to.

bipolar disorder circadian rhythm sleep disorder circadian rhythm sleep disorder, delayed sleep phase type

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DISORDER DELAYED SLEEP-WAKE PHASE DISORDER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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