Can your pupils reveal the secrets of sleep and body clocks?

NCT ID NCT07753889

Recruiting now Knowledge-focused Sponsor: Elizabeth B Klerman MD PhD Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study explores how the eyes' response to light relates to sleep patterns, circadian rhythms, and overall health. Researchers will measure pupil size under different lighting conditions and track sleep and melatonin levels in healthy volunteers and people with various medical conditions. The goal is to better understand the connections between light, the eyes, and the body's internal clock.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ocular light exposure from a portable light box
What this could lead to: If successful, this could improve understanding of how light affects sleep and body rhythms, potentially leading to better light-based therapies for sleep and circadian disorders.
What could go wrong: This is an observational study, so it won't directly test a treatment. Results may not apply to everyone, and the measures are complex, so findings might be inconclusive.

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Conditions

The condition(s) this trial relates to.

circadian rhythm sleep disorder sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCADIAN RHYTHM PUPILLOMETRY SLEEP

Contacts and locations

Locations

MassGeneralBrigham
RECRUITING

Boston, Massachusetts, 02114, United States

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