Circadian rhythm sleep disorder

This study looked at 61 night workers aged 20-55 to understand how their sleep patterns relate to attention and heart rate. Participants took ramelteon (Rozerem), a drug similar to melatonin, for two weeks. Researchers measured changes in sleep quality, anxiety, and depression us…

This study tested whether personalized sleep or nutrition advice could help night shift workers sleep better and improve their health. 57 rotating or night shift workers wore smart devices, did alertness tests, and gave blood samples. Researchers compared those who got tailored a…

This completed study tested a new radioactive tracer called [18F] - FD17 for PET imaging to detect clumps of a protein called alpha-synuclein in the brain. These clumps are linked to Parkinson's disease, multiple system atrophy, and a sleep disorder that often precedes Parkinson'…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tested whether taking hydrocortisone (a cortisol-like hormone), melatonin, or both could reduce jet lag symptoms after long eastward flights. Fifty-seven healthy adults aged 18-65 who flew across 6-8 time zones took the pills for 4 days after arrival and reported their…

This study tested whether a herbal supplement called Redormin 500 (made from valerian and hop extracts) can help people with occasional sleep problems think more clearly during the day and feel better overall. Forty healthy adults with mild sleep issues took either the supplement…

This study tested a dietary supplement called Speed Sleep in 60 adults aged 18-65 who have trouble sleeping. Participants took either the supplement or a placebo daily for 4 weeks. Sleep quality and quantity were measured using Fitbit trackers and questionnaires.

This study tested whether a self-help book could help healthcare workers with shift work disorder sleep better and feel less sleepy. 199 participants with symptoms of the disorder took part. The book provided tips on managing sleep, alertness, and health related to shift work.

This study tested whether a desk lamp that gives off near-infrared light can help people who feel sleepy or down during the day. Eighty healthy adults aged 25 to 65 used the lamp at their desk for two weeks. Researchers checked changes in mood, drowsiness, sleep quality, and bloo…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested a version of cognitive behavioral therapy for insomnia, specially adapted for night shift workers. 60 nurses who work night shifts and have insomnia took part. The goal was to see if the therapy is practical and helps improve sleep and reduce fatigue.

This small study tested whether wearing bright light glasses each morning could improve symptoms of irritable bowel syndrome (IBS) and reduce leaky gut. Five adults with IBS used the light device for two weeks. The goal was to see if the light therapy eases belly pain, bloating, …

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This study tested whether the drug Lemborexant helps people with delayed sleep phase syndrome (a condition where your natural sleep time is much later than desired) fall asleep faster. 71 adults took either the drug or a placebo nightly for up to 2 years. The main goal was to see…

This study tested whether installing special LED lights that mimic sunlight in hospital rooms could help treat depression and improve sleep. Fifteen adults with major depression participated. The goal was to see if the lights were comfortable and if they could reduce depression s…

This early study tested a product called Chenghuang Circadian Rhythm Regulator in 15 adults with ongoing sleep problems. The goal was to see if it could improve sleep quality and immune markers. Results are not yet reported, but the study was small and had no comparison group.

This study tested whether wearing a light-blocking eye mask at night (11 p.m. to 5 a.m.) could improve sleep quality and melatonin levels in 60 intensive care unit patients. Participants were randomly assigned to either wear the mask or receive standard care. Sleep quality was me…

This study tested whether a medication called lemborexant can help night shift workers sleep longer during the day. 29 full-time night shift workers who had trouble sleeping took either the drug or a placebo for two weeks. The goal was to see if the drug increased total daytime s…

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep in elderly people living in care homes. 75 residents took part, with half receiving 12 acupressure sessions over four weeks. The results showed that those who rece…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study tested a sleep and circadian treatment (TranS-C) for people with severe mental illness (SMI) in community mental health centers. The treatment was adapted to better fit these settings. Researchers looked at whether it improved sleep, daily functioning, and symptoms in …

This study tested two versions of a sleep treatment for people with severe mental illness in community mental health centers. One version was the standard treatment, and the other was adapted to better fit patients' needs. The goal was to see if training clinic staff to deliver t…

This study looked at whether adding special breathing muscle training to running programs helps 10-13-year-old male football players improve their agility, endurance, and lung function. 75 boys who had played football for at least two years took part. The training was tailored to…

This study looks at whether a 90-minute afternoon nap, a moderate dose of caffeine, and a short recovery routine (stretching plus a snack) can improve evening athletic performance. Sixty elite university athletes (30 men, 30 women) will try different combinations of these strateg…

This study tested whether bright light in the afternoon, alone or with morning light, can shift teens' internal body clocks earlier. 84 adolescents aged 18-20 followed a stable sleep schedule and then lived in a lab for a week. Researchers measured melatonin levels to track clock…

This study looks at how not getting enough sleep and being awake at odd hours affects your thinking, blood chemistry, and the helpful bacteria in your gut. Researchers gave 55 healthy adults a prebiotic supplement or a placebo to see if it could help counter the negative effects.…

This study tested whether eating 28 grams of pistachios (about 40 nuts) one hour before bedtime could help regulate the body's internal clock in 28 overweight young adults. Researchers measured melatonin levels, antioxidant activity, and sleep-wake patterns. The goal was to see i…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This completed study in Norway looked at whether delaying school start times by one to two hours on Mondays and Tuesdays helps high school students sleep longer, feel less sleepy during the day, and improve their mental health and grades. Over 580 first-year students participated…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This pilot study tested whether limiting food intake to an 8am-to-6pm window for four weeks could improve metabolic health and appetite regulation in 16 healthy adults. Participants ate freely during that window and fasted the rest of the time. The study measured changes in appet…

This study looked at how the sleep hormone melatonin and a specific gene (MTNR1B) work together to control blood sugar. Researchers tested 23 healthy adults in a controlled lab setting. The goal was to understand why some people may have higher diabetes risk, which could lead to …

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study looked at 200 heart transplant patients to see if the time of day the donor heart was removed affects how well the patient does. Researchers compared hearts taken during the body's rest phase (midnight to noon) versus the active phase (noon to midnight). They tracked s…

This study looked at whether working night shifts for just three nights in a row can disrupt bone health. Twenty healthy adults aged 20-40 either followed a normal sleep schedule or stayed awake at night and slept during the day. Researchers measured bone turnover markers to see …

This study looked at whether rotating shift workers can stick to a time-restricted eating plan, where they only eat during certain hours. Researchers wanted to see if this approach is practical and how it affects blood glucose levels during day and night shifts. 31 healthcare wor…

This study looked at how the timing of sleep affects what teenagers eat. Researchers wanted to understand why getting more sleep helps some teens eat less, but not others. They studied 190 healthy teens aged 14-18 to see if matching sleep to their natural body clock improves thei…

This study looked at whether people with binge eating disorder have a disrupted body clock. Researchers compared 43 adults with and without the condition, measuring melatonin levels and activity patterns. The goal was to understand how the circadian system might be involved, whic…

This completed observational study looked at 72 men and women aged 20-50 who work rotating night and day shifts. Researchers measured blood sugar, weight, sleep patterns, and other health markers to understand how short-term circadian misalignment from shift work affects the body…

This study looked at how lack of sleep and evening light exposure affect the body clocks of teenagers aged 14 to 17. Researchers used morning bright light to try to shift teens' sleep schedules earlier. They measured changes in melatonin levels and sleep patterns to understand wh…