New drug aims to keep night shift workers awake and safe

NCT ID NCT06568367

Recruiting now Symptom relief Sponsor: Axsome Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This Phase 3 trial tests whether the drug solriamfetol can reduce excessive sleepiness in people with shift work disorder. About 520 adults who work night shifts will take either solriamfetol or a placebo daily for 12 weeks. The study measures how well they stay awake and their overall sleepiness levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Solriamfetol (a medication that promotes wakefulness)
What this could lead to: If successful, this could provide a new treatment option to help people with shift work disorder stay awake and alert during night shifts.
What could go wrong: This is a Phase 3 trial, but solriamfetol is already approved for other sleep conditions. However, it may not work for everyone, and side effects like headache or nausea are possible.

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Conditions

The condition(s) this trial relates to.

circadian rhythm sleep disorder circadian rhythm sleep disorder, shift work type Disorders of Excessive Somnolence hypersomnia insomnia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXCESSIVE SLEEPINESS SHIFT-WORK DISORDER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Auburn, Alabama, 36832, United States
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Cullman, Alabama, 35055, United States
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Chandler, Arizona, 85224, United States
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Tucson, Arizona, 85704, United States
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Little Rock, Arkansas, 72211, United States
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Anaheim, California, 92801, United States
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Cerritos, California, 90703, United States
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Chula Vista, California, 91910, United States
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Huntington Beach, California, 92647, United States
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Long Beach, California, 90805, United States
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Santa Ana, California, 92705, United States
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Colorado Springs, Colorado, 80918, United States
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Brandon, Florida, 33511, United States
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Hialeah, Florida, 33016, United States
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Miami, Florida, 33135, United States
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Miami, Florida, 33144, United States
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Miami, Florida, 33176, United States
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Miami Lakes, Florida, 33016, United States
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Atlanta, Georgia, 30238, United States
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Stockbridge, Georgia, 30281, United States
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Chicago, Illinois, 60634, United States
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Kenner, Louisiana, 70065, United States
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Towson, Maryland, 21286, United States
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Boston, Massachusetts, 02115, United States
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Lansing, Michigan, 48911, United States
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Novi, Michigan, 48377, United States
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Southfield, Michigan, 48075, United States
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Chesterfield, Missouri, 63017, United States
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St Louis, Missouri, 63123, United States
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Henderson, Nevada, 89052, United States
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Middletown, New Jersey, 07748, United States
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Denver, North Carolina, 28037, United States
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Fayetteville, North Carolina, 28304, United States
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Huntersville, North Carolina, 28078, United States
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Cincinnati, Ohio, 45212, United States
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Cincinnati, Ohio, 45245, United States
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Wyomissing, Pennsylvania, 19610, United States
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Charleston, South Carolina, 29425, United States
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Columbia, South Carolina, 29201, United States
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Houston, Texas, 77058, United States
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Houston, Texas, 77070, United States
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San Antonio, Texas, 78229, United States
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Sugar Land, Texas, 77478, United States
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Spokane, Washington, 99204, United States
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Calgary, Alberta, T2Z 3A6, Canada
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Markham, Ontario, L3R 1A3, Canada
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Ottawa, Ontario, K2C 0P7, Canada
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Toronto, Ontario, M4N 4M5, Canada
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Toronto, Ontario, M5S 3A3, Canada

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