Tailored sleep apnea therapy shows promise for down syndrome

NCT ID NCT07280468

Recruiting now Disease control Sponsor: University of Arizona Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether matching sleep apnea treatment to the specific cause in each person with Down syndrome works better than a one-size-fits-all approach. 200 children and adults will receive either a combination of two drugs (ato-oxy) or oxygen therapy based on their individual sleep problems. The goal is to improve sleep, quality of life, and thinking skills over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atomoxetine and oxybutynin (ato-oxy) or oxygen
What this could lead to: If successful, this could make sleep apnea treatment more effective for people with Down syndrome by choosing the right therapy for each person.
What could go wrong: This is a Phase 4 study, but it is still early in testing this precision approach. The treatments may not work for everyone, and side effects like dry mouth or urinary issues are possible.

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Conditions

The condition(s) this trial relates to.

Down syndrome obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DOWN SYNDROME OBSTRUCTIVE SLEEP APNEA (OSA)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advocate Medical Group Adult Down Syndrome Center
NOT_YET_RECRUITING

Park Ridge, Illinois, 60068, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of California San Diego
NOT_YET_RECRUITING

San Diego, California, 92123, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Miami
NOT_YET_RECRUITING

Miami, Florida, 33136, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

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